Related Content
Search Google Scholar for:
|
|
Science 16 May 1986:
Vol. 232. no. 4752, pp. 884 - 886
DOI: 10.1126/science.3486470
|
|
Articles
Science, Vol 232, Issue 4752, 884-886
Copyright © 1986 by American Association for the Advancement of Science
Deregulation of c-myc by translocation of the alpha-locus of the T-cell receptor in T-cell leukemias
J Erikson,
L Finger,
L Sun,
A ar-Rushdi,
K Nishikura,
J Minowada,
J Finan,
BS Emanuel,
PC Nowell,
and
CM Croce
Two human T-cell leukemias carrying a t(8;14)(q24;q11) chromosome translocation were studied for rearrangements and expression of the c-myc oncogene. For one leukemia, rearrangement was detected in a region immediately distal (3') to the c-myc locus; no rearrangements of c-myc were observed in the second case (DeF). However, studies with hybrids between human and mouse leukemic T cells indicated that in the leukemic cells of DeF, the breakpoint in chromosome 14 occurred between genes for the variable (V alpha) and the constant (C alpha) regions for the alpha chain of the T-cell receptor. The C alpha locus had translocated to a region more than 38 kilobases 3' to the involved c-myc oncogene. Since human c-myc transcripts were expressed only in hybrids carrying the 8q+ chromosome but not in hybrids containing the normal chromosome 8, it is concluded that the translocation of the C alpha locus 3' to the c-myc oncogene can result in its transcriptional deregulation.
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
- Loss of Heterozygosity and Somatic Mutations of the Glucocorticoid Receptor Gene Are Rarely Found at Relapse in Pediatric Acute Lymphoblastic Leukemia but May Occur in a Subpopulation Early in the Disease Course.
- J. A.E. Irving, L. Minto, S. Bailey, and A. G. Hall (2005)
Cancer Res.
65, 9712-9718
| Abstract »
| Full Text »
| PDF »
- Molecular Genetics of Acute Lymphoblastic Leukemia.
- S. A. Armstrong and A. T. Look (2005)
J. Clin. Oncol.
23, 6306-6315
| Abstract »
| Full Text »
| PDF »
- Activation of the T-Cell Oncogene LMO2 after Gene Therapy for X-Linked Severe Combined Immunodeficiency.
- M. P. McCormack and T. H. Rabbitts (2004)
N. Engl. J. Med.
350, 913-922
| Full Text »
| PDF »
- Cloning of an Alpha-TFEB fusion in renal tumors harboring the t(6;11)(p21;q13) chromosome translocation.
- I. J. Davis, B.-L. Hsi, J. D. Arroyo, S. O. Vargas, Y. A. Yeh, G. Motyckova, P. Valencia, A. R. Perez-Atayde, P. Argani, M. Ladanyi, et al. (2003)
PNAS
100, 6051-6056
| Abstract »
| Full Text »
| PDF »
- The t(14;21)(q11.2;q22) chromosomal translocation associated with T-cell acute lymphoblastic leukemia activates the BHLHB1 gene.
- J. Wang, S. N. Jani-Sait, E. A. Escalon, A. J. Carroll, P. J. de Jong, I. R. Kirsch, and P. D. Aplan (2000)
PNAS
97, 3497-3502
| Abstract »
| Full Text »
| PDF »
- Clinical Significance of Cytogenetic Abnormalities in Adult Acute Lymphoblastic Leukemia.
- S. Faderl, H. M. Kantarjian, M. Talpaz, and Z. Estrov (1998)
Blood
91, 3995-4019
| Full Text »
| PDF »
- The Molecular Basis of Leukemia.
- M. J. Cline (1994)
N. Engl. J. Med.
330, 328-336
| Full Text »
- A thymus-specific member of the HMG protein family regulates the human T cell receptor C alpha enhancer..
- M L Waterman, W H Fischer, and K A Jones (1991)
Genes & Dev.
5, 656-669
| Abstract »
| PDF »
- A common mechanism of chromosomal translocation in T- and B-cell neoplasia.
- L. Finger, R. Harvey, R. Moore, L. Showe, and C. Croce (1986)
Science
234, 982-985
| Abstract »
| PDF »
- Molecular Genetics of Human B- and T-cell Neoplasia.
- C.M. Croce, J. Erikson, F.G. Haluska, L.R. Finger, L.C. Showe, and Y. Tsujimoto (1986)
Cold Spring Harb Symp Quant Biol
51, 891-898
| Abstract »
| PDF »
|
|
