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Science 16 May 1986:
Vol. 232. no. 4752, pp. 877 - 880
DOI: 10.1126/science.3010456
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Articles

Science, Vol 232, Issue 4752, 877-880
Copyright © 1986 by American Association for the Advancement of Science

articles

Trans-activator gene of HTLV-II induces IL-2 receptor and IL-2 cellular gene expression

WC Greene, WJ Leonard, Y Wano, PB Svetlik, NJ Peffer, JG Sodroski, CA Rosen, WC Goh, and WA Haseltine

The human T-lymphotropic viruses types I and II (HTLV-I and -II) have been etiologically linked with certain T-cell leukemias and lymphomas that characteristically display membrane receptors for interleukin-2. The relation of these viruses to this growth factor receptor has remained unexplained. It is demonstrated here that introduction of the trans-activator (tat) gene of HTLV-II into the Jurkat T-lymphoid cell line results in the induction of both interleukin-2 receptor and interleukin-2 gene expression. The coexpression of these cellular genes may play a role in the altering T-cell growth following retroviral infection.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Aberrant Activation of the Interleukin-2 Autocrine Loop through the Nuclear Factor of Activated T Cells by Nonleukemogenic Human T-Cell Leukemia Virus Type 2 but Not by Leukemogenic Type 1 Virus.
A. Niinuma, M. Higuchi, M. Takahashi, M. Oie, Y. Tanaka, F. Gejyo, N. Tanaka, K. Sugamura, L. Xie, P. L. Green, et al. (2005)
J. Virol. 79, 11925-11934
   Abstract »    Full Text »    PDF »
Displacement of SATB1-Bound Histone Deacetylase 1 Corepressor by the Human Immunodeficiency Virus Type 1 Transactivator Induces Expression of Interleukin-2 and Its Receptor in T Cells.
P. P. Kumar, P. K. Purbey, D. S. Ravi, D. Mitra, and S. Galande (2005)
Mol. Cell. Biol. 25, 1620-1633
   Abstract »    Full Text »    PDF »
Critical Role of Human T-Lymphotropic Virus Type 1 Accessory Proteins in Viral Replication and Pathogenesis.
B. Albrecht and M. D. Lairmore (2002)
Microbiol. Mol. Biol. Rev. 66, 396-406
   Abstract »    Full Text »    PDF »
In Vivo Genomic Footprinting of the Human T-Cell Leukemia Virus Type 1 (HTLV-1) Long Terminal Repeat Enhancer Sequences in HTLV-1-Infected Human T-Cell Lines with Different Levels of Tax I Activity.
S. Datta, N. H. Kothari, and H. Fan (2000)
J. Virol. 74, 8277-8285
   Abstract »    Full Text »
B-Lymphocyte Proliferation during Bovine Leukemia VirusInduced Persistent Lymphocytosis Is Enhanced by T-Lymphocyte-Derived Interleukin-2.
E. S. Trueblood, W. C. Brown, G. H. Palmer, W. C. Davis, D. M. Stone, and T. F. McElwain (1998)
J. Virol. 72, 3169-3177
   Abstract »    Full Text »    PDF »
Expression of a zinc finger gene in HTLV-I- and HTLV-II-transformed cells.
J. Wright, K. Gunter, H Mitsuya, S. Irving, K Kelly, and U Siebenlist (1990)
Science 248, 588-591
   Abstract »    PDF »
Retroviruses.
H Varmus (1988)
Science 240, 1427-1435
   Abstract »    PDF »
Alternative mechanisms for activation of human immunodeficiency virus enhancer in T cells.
G. Nabel, S. Rice, D. Knipe, and D Baltimore (1988)
Science 239, 1299-1302
   Abstract »    PDF »
The tat gene of human T-lymphotropic virus type 1 induces mesenchymal tumors in transgenic mice.
M Nerenberg, S. Hinrichs, R. Reynolds, G Khoury, and G Jay (1987)
Science 237, 1324-1329
   Abstract »    PDF »
Trans-activator gene of HTLV-II: interpretation.
W. Greene, W. Leonard, Y Wano, P. Svetlik, N. Peffer, J. Sodroski, C. Rosen, W. Goh, and W. Haseltine (1987)
Science 235, 1073
   PDF »
The Human Interleukin-2 Receptor: Normal and Abnormal Expression in T Cells and in Leukemias Induced by the Human T-Lymphotropic Retroviruses.
W. C. GREENE, W. J. LEONARD, J. M. DEPPER, D. L. NELSON, and T. A. WALDMANN (1986)
Ann Intern Med 105, 560-572
   Abstract »    PDF »
The Human Interleukin-2 Receptor: Role in Normal T-cell Growth and Association with HTLV-I-induced T-cell Leukemia.
W.C. Greene, J.M. Depper, M. Kronke, and W.J. Leonard (1986)
Cold Spring Harb Symp Quant Biol 51, 731-737
   Abstract »    PDF »


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