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Science 16 May 1986:
Vol. 232. no. 4752, pp. 850 - 852
DOI: 10.1126/science.3010455
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Articles

Science, Vol 232, Issue 4752, 850-852
Copyright © 1986 by American Association for the Advancement of Science

articles

Regulation of class III major histocompatibility complex gene products by interleukin-1

DH Perlmutter, G Goldberger, CA Dinarello, SB Mizel, and HR Colten

Interleukin-1 (IL-1) is a product of mononuclear phagocytes that mediates changes characteristic of the response to inflammation or tissue injury (the acute-phase response). One of two structurally and functionally homologous major histocompatibility complex (MHC) class III genes encodes a positive acute-phase protein, complement factor B. The closely linked complement C2 gene is not affected during the acute-phase response. Purified human IL-1, pH 7.0, and recombinant-generated murine IL-1, pH 5.0, increased the expression of factor B and other positive acute-phase proteins in human hepatoma cells but decreased the expression of albumin, a negative acute-phase reactant. Furthermore, in a murine fibroblast L-cell line transfected with cosmid DNA bearing the human C2 and factor B genes, IL-1 mediated a reversible dose- and time-dependent increase in factor B expression in the transfected cells. Expression of the C2 gene was not affected by IL-1. The effect of IL-1 on factor B expression involves a mechanism acting at a pre-translational level as demonstrated by an increase in specific messenger RNA content and a corresponding increase in biosynthesis and secretion of factor B. The structural basis and mechanism for selective and independent regulation of these genes provides insight into the molecular control of the inflammatory response.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Antiviral Treatment With WIN 54 954 Reduces Mortality in Murine Coxsackievirus B3 Myocarditis.
J. Fohlman, K. Pauksen, T. Hyypia, G. Eggertsen, A. Ehrnst, N.G. Ilback, and G. Friman (1996)
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   Abstract »    Full Text »
Molecular Biology of Interleukin-1.
P.T. Lomedico, P.L. Kilian, U. Gubler, A.S. Stern, and R. Chizzonite (1986)
Cold Spring Harb Symp Quant Biol 51, 631-639
   Abstract »    PDF »


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