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Science 2 May 1986:
Vol. 232. no. 4750, pp. 639 - 641
DOI: 10.1126/science.3008333
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Articles

Science, Vol 232, Issue 4750, 639-641
Copyright © 1986 by American Association for the Advancement of Science

articles

Protection of cattle against foot-and-mouth disease by a synthetic peptide

R DiMarchi, G Brooke, C Gale, V Cracknell, T Doel, and N Mowat

A chemically synthesized peptide consisting essentially of two separate regions (residues 141 to 158 and 200 to 213) of a virus coat protein (VP1) from the O1 Kaufbeuren strain of foot-and-mouth disease virus was prepared free of any carrier protein. It elicited high levels of neutralizing antibody and protected cattle against intradermolingual challenge by inoculation with infectious virus. Comparative evaluation of this peptide with a single-site peptide (residues 141 to 158) in guinea pigs suggests the importance of the VP1 carboxyl terminal residues in enhancing the protective response.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Induction of an antigen-specific immune response and partial protection of cattle against challenge infection with foot-and-mouth disease virus (FMDV) after lipopeptide vaccination with FMDV-specific B-cell epitopes.
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Intranasal Immunization of Guinea Pigs with an Immunodominant Foot-and-Mouth Disease Virus Peptide Conjugate Induces Mucosal and Humoral Antibodies and Protection against Challenge.
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Interspecies Major Histocompatibility Complex-Restricted Th Cell Epitope on Foot-and-Mouth Disease Virus Capsid Protein VP4.
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Expression in cattle of epitopes of a heterologous virus using a recombinant rinderpest virus.
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Protective Immune Response to Foot-and-Mouth Disease Virus with VP1 Expressed in Transgenic Plants.
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A retro-inverso peptide corresponding to the GH loop of foot-and-mouth disease virus elicits high levels of long-lasting protective neutralizing antibodies.
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Quantification of Myotrophin From Spontaneously Hypertensive and Normal Rat Hearts.
P. Sil, D. Mukherjee, and S. Sen (1995)
Circ. Res. 76, 1020-1027
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