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Science 2 May 1986:
Vol. 232. no. 4750, pp. 633 - 636
DOI: 10.1126/science.3008332
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Articles

Science, Vol 232, Issue 4750, 633-636
Copyright © 1986 by American Association for the Advancement of Science

articles

Crystal structure analysis of deamino-oxytocin: conformational flexibility and receptor binding

SP Wood, IJ Tickle, AM Treharne, JE Pitts, Y Mascarenhas, JY Li, J Husain, S Cooper, TL Blundell, VJ Hruby, and al. et

Two crystal structures of deamino-oxytocin have been determined at better than 1.1A resolution from isomorphous replacement and anomalous scattering x-ray measurements. In each of two crystal forms there are two closely related conformers with disulfide bridges of different chirality, which may be important in receptor recognition and activation.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Activation Mechanism of Human Oxytocin Receptor: A Combined Study of Experimental and Computer-Simulated Mutagenesis.
F. Fanelli, P. Barbier, D. Zanchetta, P. G. de Benedetti, and B. Chini (1999)
Mol. Pharmacol. 56, 214-225
   Abstract »    Full Text »
Separate Agonist and Peptide Antagonist Binding Sites of the Oxytocin Receptor Defined by Their Transfer into the V2 Vasopressin Receptor.
R. Postina, E. Kojro, and F. Fahrenholz (1996)
J. Biol. Chem. 271, 31593-31601
   Abstract »    Full Text »    PDF »
Protein hydration in aqueous solution.
G Otting, E Liepinsh, and K Wuthrich (1991)
Science 254, 974-980
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)