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Science 25 April 1986:
Vol. 232. no. 4749, pp. 522 - 524
DOI: 10.1126/science.3083508
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Articles

Science, Vol 232, Issue 4749, 522-524
Copyright © 1986 by American Association for the Advancement of Science

articles

Abnormal proteins serve as eukaryotic stress signals and trigger the activation of heat shock genes

J Ananthan, AL Goldberg, and R Voellmy

Heat shock protein (hsp) genes, a group of ubiquitous genes, are activated by various metabolic stresses. The suggestion that denaturation of intracellular proteins may be produced by the metabolic stresses and then signal the activation of the hsp genes was examined by co-injection of purified proteins and hsp genes into frog oocytes. Activation of hsp genes was observed if the proteins were denatured prior to injection but not if they were introduced in their native form. Furthermore, the activation of hsp genes by abnormal proteins and by heat shock appears to occur by a common mechanism. A model for the transcriptional regulation of the genes is based on competition for degradation between abnormal intracellular proteins and a labile regulatory factor.


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Salicylate Triggers Heat Shock Factor Differently than Heat.
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Male Germ Cell-specific Alteration in Temperature Set Point of the Cellular Stress Response.
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Differential Expression and Regulation of hsp70 and hsp90 by Phorbol Esters and Heat Shock.
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Heat-inducible DNA Binding of Purified Heat Shock Transcription Factor 1.
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In vitro manipulation of early mouse embryos induces HIV1-LTRlacZ transgene expression.
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Development 119, 1293-1300
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The human heat shock protein hsp70 interacts with HSF, the transcription factor that regulates heat shock gene expression..
K Abravaya, M P Myers, S P Murphy, and R I Morimoto (1992)
Genes & Dev. 6, 1153-1164
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Effect of sodium salicylate on the human heat shock response.
D. Jurivich, L Sistonen, R. Kroes, and R. Morimoto (1992)
Science 255, 1243-1245
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The Aging Process.
M. C. Geokas, E. G. Lakatta, T. Makinodan, and P. S. Timiras (1990)
Ann Intern Med 113, 455-466
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Escherichia coli heat shock gene mutants are defective in proteolysis..
D B Straus, W A Walter, and C A Gross (1988)
Genes & Dev. 2, 1851-1858
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Erythroid lineage-specific expression and inducibility of the major heat shock protein HSP70 during avian embryogenesis..
S S Banerji, K Laing, and R I Morimoto (1987)
Genes & Dev. 1, 946-953
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Expression of functional cell-cell channels from cloned rat liver gap junction complementary DNA.
G Dahl, T Miller, D Paul, R Voellmy, and R Werner (1987)
Science 236, 1290-1293
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Ubiquitin is a component of paired helical filaments in Alzheimer's disease.
H Mori, J Kondo, and Y Ihara (1987)
Science 235, 1641-1644
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Glycogen Synthase Kinase 3beta Negatively Regulates Both DNA-binding and Transcriptional Activities of Heat Shock Factor 1.
I. J. Xavier, P. A. Mercier, C. M. McLoughlin, A. Ali, J. R. Woodgett, and N. Ovsenek (2000)
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