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Science 25 April 1986:
Vol. 232. no. 4749, pp. 511 - 512
DOI: 10.1126/science.3008329
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Articles

Science, Vol 232, Issue 4749, 511-512
Copyright © 1986 by American Association for the Advancement of Science

articles

Receptor-associated resistance to growth hormone-releasing factor in dwarf "little" mice

JO Jansson, TR Downs, WG Beamer, and LA Frohman

Anterior pituitaries from the dwarf mouse strain "little" did not release growth hormone or accumulate adenosine 3',5'-monophosphate (cyclic AMP) in response to human and rat growth hormone-releasing factor (GRF). Dibutyryl cyclic AMP, as well as the adenylate cyclase stimulators forskolin and cholera toxin, markedly stimulated growth hormone (GH) release. The basis of the GH deficiency in the little mouse may therefore be a defect in an early stage of GRF-stimulated GH release related either to receptor binding or to the function of the hormone-receptor complex.


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