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Science 25 April 1986:
Vol. 232. no. 4749, pp. 497 - 499
DOI: 10.1126/science.3961492
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Articles

Science, Vol 232, Issue 4749, 497-499
Copyright © 1986 by American Association for the Advancement of Science

articles

Bioavailability of dioxin in soil from a 2,4,5-T manufacturing site

TH Umbreit, EJ Hesse, and MA Gallo

Dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin, TCDD) is a highly toxic contaminant produced in the manufacture of phenoxy herbicides. Despite its high TCDD content, soil from a contaminated area associated with a 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) manufacturing site in Newark, New Jersey, did not induce acute toxicity when administered to guinea pigs (the most sensitive species) by gavage. Analysis of liver samples demonstrated low bioavailability of TCDD from this soil. A comparative analysis of soils showed that Soxhlet extraction was necessary for the determination of TCDD on Newark soil, whereas solvent extraction was sufficient for soil from Times Beach, Missouri. The difference in the bioavailability of TCDD from these soils is correlated with TCDD extractability and may be related to the different compositions of the soils.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Bioavailability of the Genotoxic Components in Coal Tar Contaminated Soils in Fischer 344 Rats.
N. R. Bordelon, K. C. Donnelly, L. C. King, D. C. Wolf, W. R. Reeves, and S. E. George (2000)
Toxicol. Sci. 56, 37-48
   Abstract »    Full Text »    PDF »
Dioxin and Dioxin-Like Compounds in Soil, Part II: Technical Support Document for ATSDR Interim Policy Guideline.
C. T. De Rosa, D. Brown, R. Dhara, W. Garrett, H. Hansen, J. Holler, D. Jones, D. Jordan-Izaguirre, R. O'Connor, H. Pohl, et al. (1997)
Toxicology and Industrial Health 13, 769-804
   PDF »
Exposure and Risk Assessment with Respect to Contaminated Soil: Significance of Biomarkers and Bioavailability.
U. Rangan, C. Hedli, M. Gallo, P. Lioy, and R. Snyder (1997)
International Journal of Toxicology 16, 419-432
   Abstract »    PDF »
Application of Pharmacokinetic Principles to Exposure to Chemical Mixtures.
E. J. O'Flaherty (1989)
Toxicology and Industrial Health 5, 667-680
   Abstract »    PDF »
Scientific Trends in Risk Assessment Research.
E. L. Anderson (1989)
Toxicology and Industrial Health 5, 777-790
   Abstract »    PDF »


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