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Science 25 April 1986:
Vol. 232. no. 4749, pp. 491 - 494
DOI: 10.1126/science.3961491
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Articles

Science, Vol 232, Issue 4749, 491-494
Copyright © 1986 by American Association for the Advancement of Science

articles

Molecular analysis of the t(2;14) translocation of childhood chronic lymphocytic leukemia

HP Fell, RG Smith, and PW Tucker

Two rare cases of chronic lymphocytic leukemia (CLL) in children have been studied; both are associated with a previously undescribed chromosomal translocation [t(2;14) (p13;q32)]. In one patient the translocation was reciprocal and the breakpoint on chromosome 14 occurred just 5' of the C gamma 2 region on the productive immunoglobulin heavy-chain allele. The breakpoint on chromosome 2 does not involve the K locus but lies within an uncharacterized region that coincides with the position of a constitutive fragile site that occurs within normal lymphocytes. Data on the second patient are consistent with these findings and suggest that these cases represent a rare but distinct subgroup of CLL's with a specific cytogenetic change.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Chronic Lymphocytic Leukemia With t(2;14)(p16;q32) Involves the BCL11A and IgH Genes and Is Associated With Atypical Morphologic Features and Unmutated IgVH Genes.
C. C. Yin, K. I-C. Lin, R. P. Ketterling, R. A. Knudson, L. J. Medeiros, L. L. Barron, Y. O. Huh, R. Luthra, M. J. Keating, and L. V. Abruzzo (2009)
Am J Clin Pathol 131, 663-670
   Abstract »    Full Text »    PDF »
Lymphocyte-specific Genetic Instability and Cancer.
I.R. Kirsch, J.M. Abdallah, V.L. Bertness, M. Hale, S. Lipkowitz, F. Lista, and D.P. Lombardi (1994)
Cold Spring Harb Symp Quant Biol 59, 287-295
   Abstract »    PDF »
Chromosomal Mapping of Genes Involved in Growth Control.
U. Francke, T.L. Yang-Feng, J.E. Brissenden, and A. Ullrich (1986)
Cold Spring Harb Symp Quant Biol 51, 855-866
   Abstract »    PDF »


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