Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 18 April 1986:
Vol. 232. no. 4748, pp. 403 - 405
DOI: 10.1126/science.3485822
Prev | Table of Contents | Next

Articles

Science, Vol 232, Issue 4748, 403-405
Copyright © 1986 by American Association for the Advancement of Science

articles

Alloantigen recognition is preceded by nonspecific adhesion of cytotoxic T cells and target cells

H Spits, W van Schooten, H Keizer, G van Seventer, M van de Rijn, C Terhorst, and JE de Vries

T-cell receptors bind antigens only when the antigens are exposed on the cell surface. This can be studied best in the interaction of cytolytic T lymphocytes (CTL) with target cells because the recognition and binding event can be separated from the lytic phase. Studies with CTL clones specific for HLA-A2 and HLA-B7 demonstrated that conjugates of CTL's and target cells can be formed in the absence of specific antigen recognition. Furthermore, T-cell receptor and target antigen cannot interact unless there is conjugate formation. This indicates that nonspecific conjugate formation between CTL's and target cells precedes the recognition of specific antigen by the T-cell receptor.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Protein Kinase C{theta} Regulates Stability of the Peripheral Adhesion Ring Junction and Contributes to the Sensitivity of Target Cell Lysis by CTL.
A. M. Beal, N. Anikeeva, R. Varma, T. O. Cameron, P. J. Norris, M. L. Dustin, and Y. Sykulev (2008)
J. Immunol. 181, 4815-4824
   Abstract »    Full Text »    PDF »
ADAM-15/Metargidin Mediates Homotypic Aggregation of Human T Lymphocytes and Heterotypic Interactions of T Lymphocytes with Intestinal Epithelial Cells.
L. Charrier, Y. Yan, H. T. T. Nguyen, G. Dalmasso, C. L. Laboisse, A. T. Gewirtz, S. V. Sitaraman, and D. Merlin (2007)
J. Biol. Chem. 282, 16948-16958
   Abstract »    Full Text »    PDF »
Low affinity interaction of peptide-MHC complexes with T cell receptors.
K Matsui, J. Boniface, P. Reay, H Schild, B Fazekas de St Groth, and M. Davis (1991)
Science 254, 1788-1791
   Abstract »    PDF »
Prevention of xenograft rejection by masking donor HLA class I antigens.
D Faustman and C Coe (1991)
Science 252, 1700-1702
   Abstract »    PDF »
Structure and Regulation of the Leukocyte Adhesion Receptor LFA-1 and Its Counterreceptors, ICAM-1 and ICAM-2.
M.L. Dustin, J. Garcia-Aguilar, M.L. Hibbs, R.S. Larson, S.A. Stacker, D.E. Staunton, A.J. Wardlaw, and T.A. Springer (1989)
Cold Spring Harb Symp Quant Biol 54, 753-765
   Abstract »    PDF »
Determination of junction avidity of cytolytic T cell and target cell.
K. Sung, L. Sung, M Crimmins, S. Burakoff, and S Chien (1986)
Science 234, 1405-1408
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)