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Science 11 April 1986:
Vol. 232. no. 4747, pp. 227 - 229
DOI: 10.1126/science.3456645
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Articles

Science, Vol 232, Issue 4747, 227-229
Copyright © 1986 by American Association for the Advancement of Science

articles

Diverse gene expression for isotypes of murine serum amyloid A protein during acute phase reaction

K Yamamoto, M Shiroo, and S Migita

Serum amyloid A protein (SAA) is a precursor for a major component of amyloid fibrils, which, upon deposition, cause secondary amyloidosis in diseases such as rheumatoid arthritis. In mice, SAA is encoded by at least three genes, which show diverse expression during inflammation. Furthermore, in amyloidosis-resistant SJL mice, the gene expression for one SAA isotype, SAA2, is defective, although SAA2 gene expression is normal in amyloidosis-susceptible BALB/c mice. Because only SAA2-derived products deposit in mouse amyloid tissues, the resistance of SJL mice to amyloidosis seems to be due to defective SAA2 gene expression. Thus, the study emphasizes the importance of SAA gene structure in determining susceptibility to amyloidosis.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Inflammation-Dependent Cerebral Deposition of Serum Amyloid A Protein in a Mouse Model of Amyloidosis.
J.-t. Guo, J. Yu, D. Grass, F. C. de Beer, and M. S. Kindy (2002)
J. Neurosci. 22, 5900-5909
   Abstract »    Full Text »    PDF »
Expression of Mouse Acute-Phase (SAA1.1) and Constitutive (SAA4) Serum Amyloid A Isotypes : Influence on Lipoprotein Profiles.
M. S. Kindy, M. C. de Beer, J. Yu, and F. C. de Beer (2000)
Arterioscler Thromb Vasc Biol 20, 1543-1550
   Abstract »    Full Text »    PDF »


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