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Science 11 April 1986:
Vol. 232. no. 4747, pp. 220 - 223
DOI: 10.1126/science.3952505
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Articles

Science, Vol 232, Issue 4747, 220-223
Copyright © 1986 by American Association for the Advancement of Science

articles

Anti-idiotypic antibody vaccine for type B viral hepatitis in chimpanzees

RC Kennedy, JW Eichberg, RE Lanford, and GR Dreesman

Anti-idiotypic antibodies (anti-Id) that contain an internal image component that mimics the surface antigen of hepatitis B virus (HBsAg) were used to immunize chimpanzees. Four injections of the rabbit anti-Id preparation elicited an antibody response to HBsAg (anti-HBs). The antibody specificity appeared to be against the anti-Id, since the anti-Id immunogen was shown to bind the chimpanzee anti-HBs. Two chimpanzees immunized with the anti-Id, along with two control animals that were either untreated or received a nonimmune rabbit immunoglobulin G preparation, were challenged with infectious hepatitis B virus. Both control chimpanzees developed clinical and serological characteristics consistent with an active hepatitis B virus infection, whereas the two anti-Id treated chimpanzees were protected from infection. Since chimpanzees provide a relevant model of a human response to hepatitis B virus immunization and infection, these results indicate that anti-Id preparations such as that described here might be candidates for vaccines against human diseases.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Comparison and Characterization of Immunoglobulin G Subclasses among Primate Species.
M. H. Shearer, R. D. Dark, J. Chodosh, and R. C. Kennedy (1999)
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Anti-idiotypic Antibodies as Vaccine Candidates: The Immune Network.
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Arch Dermatol 125, 271-275
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Development and testing of AIDS vaccines.
W. Koff and D. Hoth (1988)
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