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Science 11 April 1986: Vol. 232. no. 4747, pp. 193 - 202 DOI: 10.1126/science.2937147
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Articles
Science, Vol 232, Issue 4747, 193-202
Copyright © 1986 by American Association for the Advancement of Science
Molecular genetics of human color vision: the genes encoding blue, green, and red pigments
J Nathans,
D Thomas,
and
DS Hogness
Human color vision is based on three light-sensitive pigments. The isolation and sequencing of genomic and complementary DNA clones that encode the apoproteins of these three pigments are described. The deduced amino acid sequences show 41 +/- 1 percent identity with rhodopsin. The red and green pigments show 96 percent mutual identity but only 43 percent identity with the blue pigment. Green pigment genes vary in number among color-normal individuals and, together with a single red pigment gene, are proposed to reside in a head-to-tail tandem array within the X chromosome.
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- Functional Role of Muscarinic Acetylcholine Receptor Subtype Diversity.
- A. Ashkenazi, E.G. Peralta, J.W. Winslow, J. Ramachandran, and D.J. Capon (1988)
Cold Spring Harb Symp Quant Biol
53, 263-272
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- Molecular Basis of Visual Excitation.
- L. Stryer (1988)
Cold Spring Harb Symp Quant Biol
53, 283-294
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- Structure-Function Analysis of the {beta}-Adrenergic Receptor.
- R.A.F. Dixon, I.S. Sigal, and C.D. Strader (1988)
Cold Spring Harb Symp Quant Biol
53, 487-497
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- A synaptic vesicle protein with a novel cytoplasmic domain and four transmembrane regions.
- T. Sudhof, F Lottspeich, P Greengard, E Mehl, and R Jahn (1987)
Science
238, 1142-1144
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- A New Phase in the Study of Human Inherited Eye Diseases.
- F. Wong (1987)
Arch Ophthalmol
105, 1039-1041
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