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Science 4 April 1986:
Vol. 232. no. 4746, pp. 71 - 73
DOI: 10.1126/science.3513312
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Articles

Science, Vol 232, Issue 4746, 71-73
Copyright © 1986 by American Association for the Advancement of Science

articles

Lectin activation in Giardia lamblia by host protease: a novel host-parasite interaction

B Lev, H Ward, GT Keusch, and ME Pereira

A lectin in Giardia lamblia was activated by secretions from the human duodenum, the environment where the parasite lives. Incubation of the secretions with trypsin inhibitors prevented the appearance of lectin activity, implicating proteases as the activating agent. Accordingly, lectin activation was also produced by crystalline trypsin and Pronase; other proteases tested were ineffective. When activated, the lectin agglutinated intestinal cells to which the parasite adheres in vivo. The lectin was most specific to mannose-6-phosphate and apparently was bound to the plasma membrane. Activation of a parasite lectin by a host protease represents a novel mechanism of host-parasite interaction and may contribute to the affinity of Giardia lamblia to the infection site.


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