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Science 4 April 1986:
Vol. 232. no. 4746, pp. 102 - 104
DOI: 10.1126/science.3006251
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Articles

Science, Vol 232, Issue 4746, 102-104
Copyright © 1986 by American Association for the Advancement of Science

articles

Perturbation of red cell membrane structure during intracellular maturation of Plasmodium falciparum

TF Taraschi, A Parashar, M Hooks, and H Rubin

An experimental approach, which in this study was applied to the malarial system, can be used to analyze the molecular structure and organization of individual phospholipids in a wide variety of biological membranes. Electron spin resonance spectroscopy was used to investigate the structural modifications of the major red cell phospholipids that occur in erythrocyte membranes infected with the human malarial parasite, Plasmodium falciparum. These modifications were correlated with the intracellular developmental stage of the parasite. Phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine were increasingly disordered (fluidized) as infection progressed. This disordering occurred at different rates and to varying extents.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Antimalarial Activities of Dermaseptin S4 Derivatives.
M. Krugliak, R. Feder, V. Y. Zolotarev, L. Gaidukov, A. Dagan, H. Ginsburg, and A. Mor (2000)
Antimicrob. Agents Chemother. 44, 2442-2451
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