Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 4 April 1986:
Vol. 232. no. 4746, pp. 100 - 102
DOI: 10.1126/science.3952496
Prev | Table of Contents | Next

Articles

Science, Vol 232, Issue 4746, 100-102
Copyright © 1986 by American Association for the Advancement of Science

articles

Anti-idiotypic antibodies bear the internal image of a human tumor antigen

D Herlyn, AH Ross, and H Koprowski

Goat antibodies to idiotypes (anti-idiotypic antibodies; Ab2) that recognize an idiotype associated with the combining site of a BALB/c mouse IgG2a monoclonal antibody (Ab1) to human gastric carcinoma were used to immunize BALB/c mice and rabbits. A monoclonal anti-anti-idiotypic antibody (Ab3) of IgG1 isotype was obtained after immunization of mice. The Ab3 and the Ab1 showed identical binding specificities and bound with similar avidities to the same tumor antigen. The induction of Ab1-like Ab3 by Ab2 was not restricted to mice, since Ab3 could also be induced in rabbits. Both the mouse- and the rabbit-derived Ab3 bound the same gastrointestinal cancer-associated antigen as Ab1. These findings indicate that Ab2 induced the formation of antigen-specific Ab3, probably because it bears the internal image of the tumor-associated antigen. This Ab2 may therefore have potential for modulating the immune response of cancer patients to their tumors.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Documentation of Idiotypic Cascade after Lym-1 Radioimmunotherapy in a Patient with Non-Hodgkin's Lymphoma: Basis for Extended Survival?.
B. M. Bradt, S. J. DeNardo, G. R. Mirick, and G. L. DeNardo (2003)
Clin. Cancer Res. 9, 4007S-4012
   Abstract »    Full Text »    PDF »
Induction of Ab3 and Ab3' Antibody Was Associated with Long-Term Survival after Anti-GD2 Antibody Therapy of Stage 4 Neuroblastoma.
N.-K. V. Cheung, H.-f. Guo, G. Heller, and I. Y. Cheung (2000)
Clin. Cancer Res. 6, 2653-2660
   Abstract »    Full Text »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)