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Science 28 March 1986:
Vol. 231. no. 4745, pp. 1584 - 1585
DOI: 10.1126/science.3006250
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Articles
Science, Vol 231, Issue 4745, 1584-1585
Copyright © 1986 by American Association for the Advancement of Science
Human beta-adrenoceptors: relation of myocardial and lymphocyte beta-adrenoceptor density
OE Brodde,
R Kretsch,
K Ikezono,
HR Zerkowski,
and
JC Reidemeister
In human right atria obtained from 21 patients during open-heart surgery, beta-adrenoceptor density [assessed by iodine-125-labeled (-)-cyanopindolol binding] and responsiveness (positive inotropic responses to isoprenaline) were linearly related to the beta-adrenoceptor density in the corresponding circulating lymphocytes. This direct relation of human myocardial and lymphocyte beta-adrenoceptor alterations, therefore, makes it possible to monitor drug- or disease-induced beta-adrenoceptor changes in tissues not easily accessible in humans.
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