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Science 28 March 1986:
Vol. 231. no. 4745, pp. 1574 - 1577
DOI: 10.1126/science.3006249
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Articles
Science, Vol 231, Issue 4745, 1574-1577
Copyright © 1986 by American Association for the Advancement of Science
Tissue-specific expression in transgenic mice of a fused gene containing RSV terminal sequences
PA Overbeek,
SP Lai,
KR Van Quill,
and
H Westphal
Transgenic mice were generated with pRSV-CAT, a chimeric gene construct containing the long terminal repeat of Rous sarcoma virus (RSV) linked to the bacterial gene encoding chloramphenicol acetyltransferase (CAT). CAT expression, detected in adult animals of five independent strains, was preferentially directed to organs rich in tendon, bone, and muscle. This pattern reflects the disease specificity of the intact virus and suggests that the tissue tropism of RSV is determined at least in part by the presence of endogenous tissue-specific factors that can promote expression of genetic information linked to the long terminal repeat. In two of the mouse strains, insertion of the pRSV-CAT DNA resulted in developmental abnormalities. One of these strains was characterized by a dominant trait of embryonic lethality, the other by a recessive trait of fused toes in all four feet.
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