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Science 28 March 1986:
Vol. 231. no. 4745, pp. 1567 - 1572
DOI: 10.1126/science.3006247
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Articles
Science, Vol 231, Issue 4745, 1567-1572
Copyright © 1986 by American Association for the Advancement of Science
Nucleotide sequence of SRV-1, a type D simian acquired immune deficiency syndrome retrovirus
MD Power,
PA Marx,
ML Bryant,
MB Gardner,
PJ Barr,
and
PA Luciw
Simian acquired immune deficiency syndrome (SAIDS) in the macaque genus of monkeys at the California Primate Research Center is apparently caused by infection by a type D retrovirus. The complete nucleotide sequence (8173 base pairs) of a molecular clone of the prototype SAIDS virus isolate, SRV-1, reveals a typical retrovirus structure with long terminal repeats (346 base pairs) and open reading frames for the gag (663 codons), pol (867 codons), and env (605 codons) genes. SRV-1 also has a separate open reading frame of 314 codons between the gag and pol genes that defines the viral protease gene (prt) and a short open reading frame of unknown significance downstream from the env gene. The SRV-1 protease region shows a high degree of homology to its counterpart in the hamster intracisternal A-type particle genome; both these protease genes are about twice as long as the analogous region of other retroviruses. SRV-1 has no notable similarity in either genetic organization or sequence to the human AIDS retroviruses.
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