Science 28 March 1986: Vol. 231. no. 4745, pp. 1559 - 1562 DOI: 10.1126/science.2420006

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Intravenous Hemostat: Nanotechnology to Halt Bleeding.

J. P. Bertram, C. A. Williams, R. Robinson, S. S. Segal, N. T. Flynn, and E. B. Lavik (2009)
Science Translational Medicine 1, 11ra22
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Engineered Knottin Peptides: A New Class of Agents for Imaging Integrin Expression in Living Subjects.

R. H. Kimura, Z. Cheng, S. S. Gambhir, and J. R. Cochran (2009)
Cancer Res. 69, 2435-2442
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Galectin-3 Regulates Integrin {alpha}2{beta}1-mediated Adhesion to Collagen-I and -IV.

J. Friedrichs, A. Manninen, D. J. Muller, and J. Helenius (2008)
J. Biol. Chem. 283, 32264-32272
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The GPIIb/IIIa (integrin {alpha}IIb{beta}3) odyssey: a technology-driven saga of a receptor with twists, turns, and even a bend.

B. S. Coller and S. J. Shattil (2008)
Blood 112, 3011-3025
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Low-Density Lipoprotein Specifically Binds Glycoprotein IIb/IIIa: A Flow Cytometric Method for Ligand-Receptor Interaction.

S. Tetik, F. Uras, E. Eksioglu-Demiralp, and K. Turay Yardimci (2008)
Clinical and Applied Thrombosis/Hemostasis 14, 210-219
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Quantitative Comparisons of Antibody-Binding Sites of Platelet Glycoprotein IIb/IIIa in Aplastic Anemia and Idiopathic Thrombocytopenic Purpura.

J. Kahng, H. H. Park, K. Han, B. Y. Choi, and W. Lee (2008)
Ann. Clin. Lab. Sci. 38, 6-11
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The Specificity and Function of the Metal-binding Sites in the Integrin beta3 A-domain.

M. M. Pesho, K. Bledzka, L. Michalec, C. S. Cierniewski, and E. F. Plow (2006)
J. Biol. Chem. 281, 23034-23041
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Peptide Antagonists That Inhibit Sin Nombre Virus and Hantaan Virus Entry through the {beta}3-Integrin Receptor.

R. S. Larson, D. C. Brown, C. Ye, and B. Hjelle (2005)
J. Virol. 79, 7319-7326
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Antithrombotic Effects of FK419, a Novel Nonpeptide Platelet GPIIb/IIIa Antagonist, in a Guinea Pig Photochemically Induced Middle Cerebral Artery Thrombosis Model: Comparison with Ozagrel and Argatroban.

A. Moriguchi, T. Aoki, K. Mihara, N. Tojo, N. Matsuoka, and S. Mutoh (2004)
J. Pharmacol. Exp. Ther. 308, 1094-1101
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Calcium-and integrin-binding protein regulates focal adhesion kinase activity during platelet spreading on immobilized fibrinogen.

M. U. Naik and U. P. Naik (2003)
Blood 102, 3629-3636
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Disruption of the {beta}3 663-687 disulfide bridge confers constitutive activity to {beta}3 integrins.

N. Butta, E. G. Arias-Salgado, C. Gonzalez-Manchon, M. Ferrer, S. Larrucea, M. S. Ayuso, and R. Parrilla (2003)
Blood 102, 2491-2497
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Association of CIB with GPIIb/IIIa during outside-in signaling is required for platelet spreading on fibrinogen.

U. P. Naik and M. U. Naik (2003)
Blood 102, 1355-1362
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Red Cell ICAM-4 Is a Novel Ligand for Platelet-activated alpha IIbbeta 3 Integrin.

P. Hermand, P. Gane, M. Huet, V. Jallu, C. Kaplan, H. H. Sonneborn, J.-P. Cartron, and P. Bailly (2003)
J. Biol. Chem. 278, 4892-4898
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Identification and Characterization of Two Cation Binding Sites in the Integrin beta 3 Subunit.

A. Cierniewska-Cieslak, C. S. Cierniewski, K. Blecka, M. Papierak, L. Michalec, L. Zhang, T. A. Haas, and E. F. Plow (2002)
J. Biol. Chem. 277, 11126-11134
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Kinetic Analysis of the Interaction between Vitronectin and the Urokinase Receptor.

Y. Okumura, Y. Kamikubo, S. A. Curriden, J. Wang, T. Kiwada, S. Futaki, K. Kitagawa, and D. J. Loskutoff (2002)
J. Biol. Chem. 277, 9395-9404
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Distinct Roles of Frontal and Rear Cell-Substrate Adhesions in Fibroblast Migration.

S. Munevar, Y.-l. Wang, and M. Dembo (2001)
Mol. Biol. Cell 12, 3947-3954
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Amino Acid Residues in the alpha IIb Subunit That Are Critical for Ligand Binding to Integrin alpha IIbbeta 3 Are Clustered in the beta -Propeller Model.

T. Kamata, K. K. Tieu, A. Irie, T. A. Springer, and Y. Takada (2001)
J. Biol. Chem. 276, 44275-44283
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Hemostatic Abnormalities in Cardiopulmonary Bypass: Pathophysiologic and Transfusion Considerations.

K. Kottke-Marchant and S. Sapatnekar (2001)
Seminars in Cardiothoracic and Vascular Anesthesia 5, 187-206
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Fibrinogen Stimulates Macrophage Chemokine Secretion Through Toll-Like Receptor 4.

S. T. Smiley, J. A. King, and W. W. Hancock (2001)
J. Immunol. 167, 2887-2894
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Differential antiplatelet efficacy for various GPIIb/IIIa antagonists: Role of plasma calcium levels.

S. A. Mousa, J. M. Bozarth, M. S. Forsythe, and A. Slee (2000)
Cardiovasc Res 47, 819-826
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A Leu262Pro mutation in the integrin beta 3 subunit results in an alpha IIb-beta 3 complex that binds fibrin but not fibrinogen.

C. M. Ward, A. S. Kestin, and P. J. Newman (2000)
Blood 96, 161-169
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Integrin {alpha}IIb{beta}3 Inhibitor Preserves Microvascular Patency in Experimental Acute Focal Cerebral Ischemia Editorial Comment.

T. Abumiya, R. Fitridge, C. Mazur, B. R. Copeland, J. A. Koziol, J. F. Tschopp, M. D. Pierschbacher, G. J. del Zoppo, and P. D. Hurn (2000)
Stroke 31, 1402-1410
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Foot-and-mouth disease virus is a ligand for the high-affinity binding conformation of integrin {alpha}5{beta}1: influence of the leucine residue within the RGDL motif on selectivity of integrin binding.

T. Jackson, W. Blakemore, J. W. I. Newman, N. J. Knowles, A. P. Mould, M. J. Humphries, and A. M. Q. King (2000)
J. Gen. Virol. 81, 1383-1391
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Fibronectin in an Extracellular Matrix of Cultured Endothelial Cells Supports Platelet Adhesion via Its Ninth Type III Repeat : A Comparison With Platelet Adhesion to Isolated Fibronectin.

S. Beumer, G. J. Heijnen-Snyder, M. J. W. IJsseldijk, P. G. de Groot, and J. J. Sixma (2000)
Arterioscler Thromb Vasc Biol 20 , e16-e25
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Comparative In Vitro Efficacy of Different Platelet Glycoprotein IIb/IIIa Antagonists on Platelet-Mediated Clot Strength Induced by Tissue Factor With Use of Thromboelastography : Differentiation Among Glycoprotein IIb/IIIa Antagonists.

S. A. Mousa, S. Khurana, and M. S. Forsythe (2000)
Arterioscler Thromb Vasc Biol 20, 1162-1167
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{alpha}v Integrin regulates TNF-{alpha}-induced nitric oxide synthesis in rat mesangial cells—possible role of osteopontin.

T. Nagasaki, E. Ishimura, H. Koyama, A. Shioi, S. Jono, M. Inaba, T. Hasuma, M. Yokoyama, Y. Nishizawa, H. Morii, et al. (1999)
Nephrol. Dial. Transplant. 14, 1861-1866
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Peptide Ligands Can Bind to Distinct Sites in Integrin alpha IIbbeta 3 and Elicit Different Functional Responses.

C. S. Cierniewski, T. Byzova, M. Papierak, T. A. Haas, J. Niewiarowska, L. Zhang, M. Cieslak, and E. F. Plow (1999)
J. Biol. Chem. 274, 16923-16932
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Molecular Genetic Analysis of a Compound Heterozygote for the Glycoprotein (GP) IIb Gene Associated With Glanzmann's Thrombasthenia: Disruption of the 674-687 Disulfide Bridge in GPIIb Prevents Surface Exposure of GPIIb-IIIa Complexes.

C. Gonzalez-Manchon, M. Fernandez-Pinel, E. G. Arias-Salgado, M. Ferrer, M.-V. Alvarez, S. Garcia-Munoz, M. S. Ayuso, and R. Parrilla (1999)
Blood 93, 866-875
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Definition of an Unexpected Ligand Recognition Motif for alpha vbeta 6 Integrin.

S. Kraft, B. Diefenbach, R. Mehta, A. Jonczyk, G. A. Luckenbach, and S. L. Goodman (1999)
J. Biol. Chem. 274, 1979-1985
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Activation of {alpha}V{beta}3 on Vascular Cells Controls Recognition of Prothrombin.

T. V. Byzova and E. F. Plow (1998)
J. Cell Biol. 143, 2081-2092
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Glycoprotein IIb/IIIa Integrin Blockade.

M. Madan, S. D. Berkowitz, and J. E. Tcheng (1998)
Circulation 98, 2629-2635
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Antiplatelet Efficacy of XV459, A Novel Nonpeptide Platelet GPIIb/IIIa Antagonist: Comparative Platelet Binding Profiles with c7E3.

S. A. Mousa, J. M. Bozarth, W. Lorelli, M. S. Forsythe, M. J. M. C. Thoolen, A. M. Slee, T. M. Reilly, and P. A. Friedman (1998)
J. Pharmacol. Exp. Ther. 286, 1277-1284
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A Sequence within the Cytoplasmic Tail of GpIIb Independently Activates Platelet Aggregation and Thromboxane Synthesis.

G. Stephens, N. O'Luanaigh, D. Reilly, P. Harriott, B. Walker, D. Fitzgerald, and N. Moran (1998)
J. Biol. Chem. 273, 20317-20322
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ß3-Integrins Rather Than ß1-Integrins Dominate Integrin-Matrix Interactions Involved in Postinjury Smooth Muscle Cell Migration.

M. J. Slepian, S. P. Massia, B. Dehdashti, A. Fritz, and L. Whitesell (1998)
Circulation 97, 1818-1827
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Binding to Human Extracellular Matrix by Neisseria meningitidis.

T. Eberhard, R. Virkola, T. Korhonen, G. Kronvall, and M. Ullberg (1998)
Infect. Immun. 66, 1791-1794
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Binding of [3H]-SK&F 107260 and [3H]-SB 214857 to Purified Integrin alpha IIbbeta 3: Evidence for a Common Binding Site for Cyclic Arginyl-Glycinyl-Aspartic Acid Peptides and Nonpeptides.

A. Wong, S. M. Hwang, K. Johanson, J. Samanen, D. Bennett, S. W. Landvatter, W. Chen, J. R. Heys, F. E. Ali, T. W. Ku, et al. (1998)
J. Pharmacol. Exp. Ther. 285, 228-235
 |  Abstract »  |  Full Text »

Adhesion of Human Umbilical Vein Endothelial Cells to the Immediate-Early Gene Product Cyr61 Is Mediated through Integrin alpha vbeta 3.

M. L. Kireeva, S. C.-T. Lam, and L. F. Lau (1998)
J. Biol. Chem. 273, 3090-3096
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Triflavin Inhibits Platelet-Induced Vasoconstriction in De-endothelialized Aorta.

J.-R. Sheu, M. H. Yen, W. C. Hung, Y. M. Lee, C. H. Su, and T. F. Huang (1997)
Arterioscler Thromb Vasc Biol 17, 3461-3468
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Selective {alpha}v{beta}3 integrin blockade potently limits neointimal hyperplasia and lumen stenosis following deep coronary arterial stent injury:: Evidence for the functional importance of integrin {alpha}v{beta}3 and osteopontin expression during neointima formation.

S.S. Srivatsa, L. A Fitzpatrick, P. W Tsao, T. M Reilly, D. R Holmes Jr, R. S Schwartz, and S. A Mousa (1997)
Cardiovasc Res 36, 408-428
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The Human Integrin beta 3 Gene Is 63 kb and Contains a 5'-UTR Sequence Regulating Expression.

C. C. Wilhide, Y. Jin, Q. Guo, L. Li, S.-X. Li, E. Rubin, and P. F. Bray (1997)
Blood 90, 3951-3961
 |  Abstract »  |  Full Text »  |  PDF »

Continued Thromboxane A2 Formation Despite Administration of a Platelet Glycoprotein IIb/IIIa Antagonist in Patients Undergoing Coronary Angioplasty.

A. Byrne, N. Moran, M. Maher, N. Walsh, P. Crean, and D. J. Fitzgerald (1997)
Arterioscler Thromb Vasc Biol 17, 3224-3229
 |  Abstract »  |  Full Text »

Networking in the Hemostatic System. INTEGRIN alpha IIbbeta 3 BINDS PROTHROMBIN AND INFLUENCES ITS ACTIVATION.

T. V. Byzova and E. F. Plow (1997)
J. Biol. Chem. 272, 27183-27188
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alpha 4 Integrin Binding Interfaces on VCAM-1 and MAdCAM-1. INTEGRIN BINDING FOOTPRINTS IDENTIFY ACCESSORY BINDING SITES THAT PLAY A ROLE IN INTEGRIN SPECIFICITY.

P. Newham, S. E. Craig, G. N. Seddon, N. R. Schofield, A. Rees, R. M. Edwards, E. Y. Jones, and M. J. Humphries (1997)
J. Biol. Chem. 272, 19429-19440
 |  Abstract »  |  Full Text »  |  PDF »

Prevention of Carotid Artery Thrombosis by Oral Platelet GPIIb/IIIa Antagonist in Dogs.

S. A. Mousa, D.-X. Mu, and B. R. Lucchesi (1997)
Stroke 28, 830-836
 |  Abstract »  |  Full Text »

Integrin-dependent Activation of the p70 Ribosomal S6 Kinase Signaling Pathway.

R. K. Malik and J. T. Parsons (1996)
J. Biol. Chem. 271, 29785-29791
 |  Abstract »  |  Full Text »  |  PDF »

Vascular Smooth Muscle {alpha}vß3 Integrin Mediates Arteriolar Vasodilation in Response to RGD Peptides.

J. E. Mogford, G. E. Davis, S. H. Platts, and G. A. Meininger (1996)
Circ. Res. 79, 821-826
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Critical Residues of Integrin alpha IIb Subunit for Binding of alpha IIbbeta 3 (Glycoprotein IIb-IIIa) to Fibrinogen and Ligand-mimetic Antibodies (PAC-1, OP-G2, and LJ-CP3).

T. Kamata, A. Irie, M. Tokuhira, and Y. Takada (1996)
J. Biol. Chem. 271, 18610-18615
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The Ligand Recognition Specificity of beta(3) Integrins.

K. Suehiro, J. W. Smith, and E. F. Plow (1996)
J. Biol. Chem. 271, 10365-10371
 |  Abstract »  |  Full Text »  |  PDF »

Oral Antiplatelet, Antithrombotic Efficacy of DMP 728, a Novel Platelet GPIIb/IIIa Antagonist.

S. A. Mousa, W. F. DeGrado, D.-X. Mu, R. P. Kapil, B. R. Lucchesi, and T. M. Reilly (1996)
Circulation 93, 537-543
 |  Abstract »  |  Full Text »

Substitutions of Proline 42 to Alanine and Methionine 46 to Asparagine around the RGD Domain of the Neurotoxin Dendroaspin Alter Its Preferential Antagonism to That Resembling the Disintegrin Elegantin.

X. Lu, S. Rahman, V. V. Kakkar, and K. S. Authi (1996)
J. Biol. Chem. 271, 289-294
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Interaction of Integrin alpha[IMAGE]beta(3) with Multiple Fibrinogen Domains during Platelet Adhesion.

B. Savage, E. Bottini, and Z. M. Ruggeri (1995)
J. Biol. Chem. 270, 28812-28817
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A Monoclonal Antibody That Recognizes the GPIIb/IIIa Antagonist DMP 728 : Reversal of the Effects of DMP 728 on Platelet Aggregation and Bleeding Time in the Dog.

T. M. Reilly, S. A. Mousa, A. L. Racanelli, M. J. Thoolen, S. K. Flint, J. M. Bozarth, D. X. Mu, and H. L. Walton (1995)
Arterioscler Thromb Vasc Biol 15, 2195-2199
 |  Abstract »  |  Full Text »

Glucocorticoids Increase Osteopontin Expression in Cardiac Myocytes and Microvascular Endothelial Cells.

K. Singh, J.-L. Balligand, T. A. Fischer, T. W. Smith, and R. A. Kelly (1995)
J. Biol. Chem. 270, 28471-28478
 |  Abstract »  |  Full Text »  |  PDF »

Blockade of Platelet GPIIb/IIIa Receptors as an Antithrombotic Strategy.

B. S. Coller (1995)
Circulation 92, 2373-2380
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Requirement for the Synergy Site for Cell Adhesion to Fibronectin Depends on the Activation State of Integrin alpha5beta1.

E. H. J. Danen, S.-i. Aota, A. A. van Kraats, K. M. Yamada, D. J. Ruiter, and G. N. P. van Muijen (1995)
J. Biol. Chem. 270, 21612-21618
 |  Abstract »  |  Full Text »  |  PDF »

The Exchange of Arg-Gly-Asp (RGD) and Arg-Tyr-Asp (RYD) Binding Sequences in a Recombinant Murine Fab Fragment Specific for the Integrin [IMAGE][IMAGE][IMAGE][IMAGE] Does Not Alter Integrin Recognition.

T. J. Kunicki, K. R. Ely, T. C. Kunicki, Y. Tomiyama, and D. S. Annis (1995)
J. Biol. Chem. 270, 16660-16665
 |  Abstract »  |  Full Text »  |  PDF »

SC-54684A: An Orally Active Inhibitor of Platelet Aggregation.

N. S. Nicholson, S. G. Panzer-Knodle, A. K. Salyers, B. B. Taite, J. A. Szalony, N. F. Haas, L. W. King, J. A. Zablocki, B. T. Keller, K. Broschat, et al. (1995)
Circulation 91, 403-410
 |  Abstract »  |  Full Text »

An anti-alpha v-integrin antibody that blocks integrin function inhibits the development of a human melanoma in nude mice.

F Mitjans, D Sander, J Adan, A Sutter, J. Martinez, C. Jaggle, J. Moyano, H. Kreysch, J Piulats, and S. Goodman (1995)
J. Cell Sci. 108, 2825-2838
 |  Abstract »  |  PDF »

Ligand Binding to Integrins: Dynamic Regulation and Common Mechanisms.

M.H. Ginsberg, T.E. O'Toole, J.C. Loftus, and E.F. Plow (1992)
Cold Spring Harb Symp Quant Biol 57, 221-231
 |  Abstract »  |  PDF »

A beta 3 integrin mutation abolishes ligand binding and alters divalent cation-dependent conformation.

J. Loftus, T. O'Toole, E. Plow, A Glass, A. Frelinger 3rd, and M. Ginsberg (1990)
Science 249, 915-918
 |  Abstract »  |  PDF »

Localization of an Arg-Gly-Asp recognition site within an integrin adhesion receptor.

S. D'Souza, M. Ginsberg, T. Burke, S. Lam, and E. Plow (1988)
Science 242, 91-93
 |  Abstract »  |  PDF »

New perspectives in cell adhesion: RGD and integrins.

E Ruoslahti and M. Pierschbacher (1987)
Science 238, 491-497
 |  Abstract »  |  PDF »

A Model of Platelet Aggregation Involving Multiple Interactions of Thrombospondin-1, Fibrinogen, and GPIIbIIIa Receptor.

A. Bonnefoy, R. Hantgan, C. Legrand, and M. M. Frojmovic (2001)
J. Biol. Chem. 276, 5605-5612
 |  Abstract »  |  Full Text »  |  PDF »

Calcium Integrin-binding Protein Activates Platelet Integrin alpha IIbbeta 3.

S. Tsuboi (2002)
J. Biol. Chem. 277, 1919-1923
 |  Abstract »  |  Full Text »  |  PDF »

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