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Science 28 March 1986:
Vol. 231. no. 4745, pp. 1553 - 1555
DOI: 10.1126/science.3006245
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Articles
Science, Vol 231, Issue 4745, 1553-1555
Copyright © 1986 by American Association for the Advancement of Science
Identification of HTLV-III/LAV sor gene product and detection of antibodies in human sera
NC Kan,
G Franchini,
F Wong-Staal,
GC DuBois,
WG Robey,
JA Lautenberger,
and
TS Papas
The nucleotide sequence of the genome of HTLV-III, the infectious agent etiologically associated with the acquired immune deficiency syndrome, predicts a small open reading frame, termed sor, located between the pol and env genes. A DNA segment containing 82 percent of the sor region was inserted into a prokaryotic expression vector, pJL6, to determine whether sor encodes a viral protein and to gain some insight into its possible function. The bacterially synthesized sor protein reacted with sera from individuals infected with HTLV-III, indicating that sor is expressed as a protein product or products that are immunogenic in vivo. Antibodies to the purified, bacterially synthesized sor protein were found to react specifically with the same protein and also with a protein of molecular weight 23,000 (23K) in HTLV-III-infected H9 cell extracts. The 23K protein comigrated with a protein immunoprecipitated by the serum of a hemophiliac patient with antibodies to HTLV-III, suggesting that this protein is probably the sor gene product.
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