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Science 21 March 1986:
Vol. 231. no. 4744, pp. 1393 - 1398
DOI: 10.1126/science.3082006
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Articles

Science, Vol 231, Issue 4744, 1393-1398
Copyright © 1986 by American Association for the Advancement of Science

articles

Rates of DNA sequence evolution differ between taxonomic groups

RJ Britten

The mutation rates of DNA sequences during evolution can be estimated from interspecies DNA sequence differences by assaying changes that have little or no effect on the phenotype (neutral mutations). Examination of available measurements shows that rates of DNA change of different phylogenetic groups differ by a factor of 5. The slowest rates are observed for higher primates and some bird lineages, while faster rates are seen in rodents, sea urchins, and drosophila. The rate of DNA sequence change has decreased markedly during primate evolution. The contrast in rates of DNA sequence change is probably due to evolutionary variation and selection of biochemical mechanisms such as DNA replication or repair.


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