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Science 7 March 1986:
Vol. 231. no. 4742, pp. 1145 - 1147
DOI: 10.1126/science.2935937

Articles

Science, Vol 231, Issue 4742, 1145-1147
Copyright © 1986 by American Association for the Advancement of Science


articles

Atrial natriuretic peptide elevation in congestive heart failure in the human

JC Burnett Jr, PC Kao, DC Hu, DW Heser, D Heublein, JP Granger, TJ Opgenorth, and GS Reeder

A sensitive radioimmunoassay for atrial natriuretic peptide was used to examine the relation between circulating atrial natriuretic peptide and cardiac filling pressure in normal human subjects, in patients with cardiovascular disease and normal cardiac filling pressure, and in patients with cardiovascular disease and elevated cardiac filling pressure with and without congestive heart failure. The present studies establish a normal range for atrial natriuretic peptide in normal human subjects. These studies also establish that elevated cardiac filling pressure is associated with increased circulating concentrations of atrial natriuretic peptide and that congestive heart failure is not characterized by a deficiency in atrial natriuretic peptide, but with its elevation.


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Differential Secretion of Atrial and Brain Natriuretic Peptide in Critically Ill Patients.
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C Briguori, S Betocchi, F Manganelli, B Gigante, M.A Losi, Q Ciampi, R Gottilla, A Violante, C.G Tocchetti, M Volpe, et al. (2001)
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L. V. d'Uscio, T. Quaschning, J. C. Burnett Jr, and T. F. Luscher (2001)
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Subcutaneous administration of brain natriuretic peptide in experimental heart failure.
H. H. Chen, J. A. Grantham, J. A. Schirger, M. Jougasaki, M. M. Redfield, and J. C. Burnett Jr. (2000)
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Insufficient secretion of atrial natriuretic peptide at acute phase of myocardial infarction.
K. Maeda, T. Tsutamoto, A. Wada, N. Mabuchi, M. Hayashi, T. Hisanaga, T. Kamijo, and M. Kinoshita (2000)
J Appl Physiol 89, 458-464
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Mechanical Unloading Versus Neurohumoral Stimulation on Myocardial Structure and Endocrine Function In Vivo.
O. Lisy, M. M. Redfield, S. Jovanovic, M. Jougasaki, A. Jovanovic, H. Leskinen, A. Terzic, and J. C. Burnett Jr (2000)
Circulation 102, 338-343
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ANP in regulation of arterial pressure and fluid-electrolyte balance: lessons from genetic mouse models.
L. G. MELO, M. E. STEINHELPER, S. C. PANG, Y. TSE, and U. ACKERMANN (2000)
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Atrial Natriuretic Factor Binding to Its Receptor Is Dependent on Chloride Concentration : A Possible Feedback-Control Mechanism in Renal Salt Regulation.
K. S. Misono (2000)
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Natriuretic peptide levels in atrial fibrillation: A prospective hormonal and Doppler-echocardiographic study.
A. Rossi, M. Enriquez-Sarano, J. C. Burnett Jr., A. Lerman, M. D. Abel, and J. B. Seward (2000)
J. Am. Coll. Cardiol. 35, 1256-1262
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Neurohormonal activation late after cavopulmonary connection.
V E Hjortdal, E V Stenbøg, H B Ravn, K Emmertsen, K T Jensen, E B Pedersen, K H Olsen, O K Hansen, and K E Sørensen (2000)
Heart 83, 439-443
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Is the secretion of atrial natriuretic peptide in man under neural control?.
G McDowell, M Cave, A Bainbridge, M Danton, C Shaw, K.D Buchanan, J Wallwork, S Large, and D.P Nicholls (2000)
Eur. Heart J. 21, 498-503
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The modulating actions of sulfonylurea on atrial natriuretic peptide release in experimental acute heart failure.
H. H. Chen, K. Y. Oh, A. Terzic, and J. C. Burnett Jr. (2000)
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Effects of natriuretic peptides on load and myocardial function in normal and heart failure dogs.
J. G. Lainchbury, J. C. Burnett Jr., D. Meyer, and M. M. Redfield (2000)
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Renal Response to Acute Neutral Endopeptidase Inhibition in Mild and Severe Experimental Heart Failure.
H. H. Chen, J. A. Schirger, W. L. Chau, M. Jougasaki, O. Lisy, M. M. Redfield, P. T. Barclay, and J. C. Burnett Jr (1999)
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S. Z. Kim, K. W. Cho, and S. H. Kim (1999)
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   Abstract »    Full Text »    PDF »
Low-Dose C-Type Natriuretic Peptide Does Not Affect Cardiac and Renal Function in Humans.
G. Barletta, C. Lazzeri, S. Vecchiarino, R. Del Bene, G. Messeri, A. Dello Sbarba, M. Mannelli, and G. La Villa (1998)
Hypertension 31, 802-808
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Na+ influx and Na+-K+ pump activation during short-term exposure of cardiac myocytes to aldosterone.
A. S. Mihailidou, K. A. Buhagiar, and H. H. Rasmussen (1998)
Am J Physiol Cell Physiol 274, C175-C181
   Abstract »    Full Text »    PDF »
Neutral Endopeptidase Regulates C-Type Natriuretic Peptide Metabolism But Does Not Potentiate Its Bioactivity In Vivo.
R. R. Brandt, M. T. Mattingly, A. L. Clavell, P. L. Barclay, and J. C. Burnett Jr (1997)
Hypertension 30, 184-190
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Superiority of Brain Natriuretic Peptide as a Hormonal Marker of Ventricular Systolic and Diastolic Dysfunction and Ventricular Hypertrophy.
K. Yamamoto, J. C. Burnett Jr, M. Jougasaki, R. A. Nishimura, K. R. Bailey, Y. Saito, K. Nakao, and M. M. Redfield (1996)
Hypertension 28, 988-994
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Evidence for Functional Relevance of an Enhanced Expression of the Na+-Ca2+ Exchanger in Failing Human Myocardium.
M. Flesch, R. H.G. Schwinger, F. Schiffer, K. Frank, M. Sudkamp, F. Kuhn-Regnier, G. Arnold, and M. Bohm (1996)
Circulation 94, 992-1002
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Angiotensin II in the Evolution of Experimental Heart Failure.
A. Luchner, T. L. Stevens, D. D. Borgeson, M. M. Redfield, J. E. Bailey, S. M. Sandberg, D. M. Heublein, and J. C. Burnett (1996)
Hypertension 28, 472-477
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Differing Metabolism and Bioactivity of Atrial and Brain Natriuretic Peptides in Essential Hypertension.
G. B. Pidgeon, A. M. Richards, M. G. Nicholls, E. A. Espiner, T. G. Yandle, and C. Frampton (1996)
Hypertension 27, 906-913
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Natriuretic Peptide Receptors in Human Artery and Vein and Rabbit Vein Graft.
T. Ikeda, H. Itoh, Y. Komatsu, M. Hanyu, T. Yoshimasa, K. Matsuda, K. Nakao, and T. Ban (1996)
Hypertension 27, 833-837
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ATRIAL NATIURETIC PEPTIDE RELEASE AT REST AND WITH EXERCISE AFTER CARDIAC TRANSPLANTATION WITH BICAVAL ANASTOMOSES.
A. W. Jahnke, R. Leyh, A. Bernhard, and H. H. Sievers (1995)
J. Thorac. Cardiovasc. Surg. 110, 1600-1605
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Expression of Renin-Angiotensin System Components in the Heart, Kidneys, and Lungs of Rats With Experimental Heart Failure.
F. Pieruzzi, Z. A. Abassi, and H. R. Keiser (1995)
Circulation 92, 3105-3112
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Inhibition by Cardiac Natriuretic Peptides of Rat Vascular Endothelial Cell Migration.
M. Ikeda, M. Kohno, and T. Takeda (1995)
Hypertension 26, 401-405
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Elevation of Circulating and Ventricular Adrenomedullin in Human Congestive Heart Failure.
M. Jougasaki, C.-M. Wei, L. J. McKinley, and J. C. Burnett Jr (1995)
Circulation 92, 286-289
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Influence of Atrial Natriuretic Factor on Spontaneous Baroreflex Sensitivity for Heart Rate in Humans.
G. C. Butler, B. L. Senn, and J. S. Floras (1995)
Hypertension 25, 1167-1171
   Abstract »    Full Text »



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