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Science 7 March 1986:
Vol. 231. no. 4742, pp. 1118 - 1122
DOI: 10.1126/science.2935936
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Articles

Science, Vol 231, Issue 4742, 1118-1122
Copyright © 1986 by American Association for the Advancement of Science

articles

Identification of a T helper cell-derived lymphokine that activates resting T lymphocytes

C Milanese, NE Richardson, and EL Reinherz

A novel lymphokine with apparent molecular size of 10 to 12 kilodaltons is secreted from helper T cell clones within hours after cross-linking their T cell antigen-MHC (major histocompatibility complex) receptors (T3-Ti). This lymphokine, termed interleukin-4A (IL-4A), stimulates resting lymphocytes by binding to a surface component (or components) of the alternative T11 pathway and subsequently by inducing interleukin-2 (IL-2) receptors. The activation process is neither dependent on antigen specificities of the recruited population or the presence of macrophages. It appears, therefore, that IL-4A is a mediator involved in amplifying the T cell immune response.


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