Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 28 February 1986:
Vol. 231. no. 4741, pp. 987 - 989
DOI: 10.1126/science.3080808
Prev | Table of Contents | Next

Articles

Science, Vol 231, Issue 4741, 987-989
Copyright © 1986 by American Association for the Advancement of Science

articles

Selectivity of the parkinsonian neurotoxin MPTP: toxic metabolite MPP+ binds to neuromelanin

RJ D'Amato, ZP Lipman, and SH Snyder

Methylphenyltetrahydropyridine (MPTP) selectively destroys neuronal cell bodies in the melanin-containing substantia nigra of humans and other primates. We show that methylphenylpyridine (MPP+), an active metabolite of MPTP which is accumulated intraneuronally by the catecholamine uptake system, binds with high affinity to melanin and neuromelanin. MPP+ bound intracellularly to neuromelanin may be released gradually, resulting in subsequent damage to the neurons of the substantia nigra.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
New melanic pigments in the human brain that accumulate in aging and block environmental toxic metals.
L. Zecca, C. Bellei, P. Costi, A. Albertini, E. Monzani, L. Casella, M. Gallorini, L. Bergamaschi, A. Moscatelli, N. J. Turro, et al. (2008)
PNAS 105, 17567-17572
   Abstract »    Full Text »    PDF »
A proposed dual role of neuromelanin in the pathogenesis of Parkinson's disease..
L. Zecca, F. A. Zucca, A. Albertini, E. Rizzio, and R. G. Fariello (2006)
Neurology 67, S8-11
   Abstract »    Full Text »
From the Cover: The surface oxidation potential of human neuromelanin reveals a spherical architecture with a pheomelanin core and a eumelanin surface.
W. D. Bush, J. Garguilo, F. A. Zucca, A. Albertini, L. Zecca, G. S. Edwards, R. J. Nemanich, and J. D. Simon (2006)
PNAS 103, 14785-14789
   Abstract »    Full Text »    PDF »
The role of iron and copper molecules in the neuronal vulnerability of locus coeruleus and substantia nigra during aging.
L. Zecca, A. Stroppolo, A. Gatti, D. Tampellini, M. Toscani, M. Gallorini, G. Giaveri, P. Arosio, P. Santambrogio, R. G. Fariello, et al. (2004)
PNAS 101, 9843-9848
   Abstract »    Full Text »    PDF »
Substantia nigra neuromelanin: structure, synthesis, and molecular behaviour.
L Zecca, D Tampellini, M Gerlach, P Riederer, R G Fariello, and D Sulzer (2001)
Mol. Pathol. 54, 414-418
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)