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Science 28 February 1986:
Vol. 231. no. 4741, pp. 1002 - 1004
DOI: 10.1126/science.2868526
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Articles

Science, Vol 231, Issue 4741, 1002-1004
Copyright © 1986 by American Association for the Advancement of Science

articles

Gonadotroph-specific expression of metallothionein fusion genes in pituitaries of transgenic mice

MJ Low, RM Lechan, RE Hammer, RL Brinster, JF Habener, G Mandel, and RH Goodman

Transgenic mice expressing a metallothionein-somatostatin fusion gene contain high concentrations of somatostatin in the anterior pituitary gland, a tissue that does not normally produce somatostatin. Immunoreactive somatostatin within the anterior pituitaries was found exclusively within gonadotrophs. Similarly, a metallothionein-human growth-hormone fusion gene was also expressed selectively in gonadotrophs. It is proposed that sequences common to the two fusion genes are responsible for the gonadotroph-specific expression.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Cellular Specificity of Proexendin-4 Processing in Mammalian Cells in Vitro and in Vivo.
F. A. Adatia, L. L. Baggio, Q. Xiao, D. J. Drucker, and P. L. Brubaker (2002)
Endocrinology 143, 3464-3471
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Science. ISSN 0036-8075 (print), 1095-9203 (online)