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Science 21 February 1986:
Vol. 231. no. 4740, pp. 856 - 859
DOI: 10.1126/science.3080807
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Articles

Science, Vol 231, Issue 4740, 856-859
Copyright © 1986 by American Association for the Advancement of Science

articles

Detection of alpha-transducin in retinal rods but not cones

GB Grunwald, P Gierschik, M Nirenberg, and A Spiegel

The distribution in chicken retina of the alpha subunit of transducin, the guanine nucleotide--binding protein that couples light-dependent activation of rhodopsin with activation of guanosine 3',5'-monophosphate phosphodiesterase, was determined with the aid of a specific antiserum. alpha-Transducin was found in rod photoreceptor cells but was not detected in cones. These results show that rods and cones differ with respect to alpha-transducin content and suggest that the processes of phototransduction may differ correspondingly in rods and cones.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A Retinal-Specific Regulator of G-Protein Signaling Interacts with G{alpha}o and Accelerates an Expressed Metabotropic Glutamate Receptor 6 Cascade.
A. Dhingra, E. Faurobert, N. Dascal, P. Sterling, and N. Vardi (2004)
J. Neurosci. 24, 5684-5693
   Abstract »    Full Text »    PDF »
Species-Specific Differences in Expression of G-Protein-Coupled Receptor Kinase (GRK) 7 and GRK1 in Mammalian Cone Photoreceptor Cells: Implications for Cone Cell Phototransduction.
E. R. Weiss, M. H. Ducceschi, T. J. Horner, A. Li, C. M. Craft, and S. Osawa (2001)
J. Neurosci. 21, 9175-9184
   Abstract »    Full Text »    PDF »
Expression of transducin in retinal rod photoreceptor outer segments.
D. Roof and C. Heth (1988)
Science 241, 845-847
   PDF »
Cone cell-specific genes expressed in retinoblastoma.
E Bogenmann, M. Lochrie, and M. Simon (1988)
Science 240, 76-78
   Abstract »    PDF »
Diurnal expression of transducin mRNA and translocation of transducin in rods of rat retina.
M. Brann and L. Cohen (1987)
Science 235, 585-587
   Abstract »    PDF »
Identification of specific transducin alpha subunits in retinal rod and cone photoreceptors.
C. Lerea, D. Somers, J. Hurley, I. Klock, and A. Bunt-Milam (1986)
Science 234, 77-80
   Abstract »    PDF »
Phototransduction in transgenic mice after targeted deletion of the rod transducin alpha -subunit.
P. D. Calvert, N. V. Krasnoperova, A. L. Lyubarsky, T. Isayama, M. Nicolo, B. Kosaras, G. Wong, K. S. Gannon, R. F. Margolskee, R. L. Sidman, et al. (2000)
PNAS 97, 13913-13918
   Abstract »    Full Text »    PDF »


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