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Science 21 February 1986:
Vol. 231. no. 4740, pp. 843 - 845
DOI: 10.1126/science.3945812
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Articles

Science, Vol 231, Issue 4740, 843-845
Copyright © 1986 by American Association for the Advancement of Science

articles

L-isoleucine and L-leucine: tumor promoters of bladder cancer in rats

Y Nishio, T Kakizoe, M Ohtani, S Sato, T Sugimura, and S Fukushima

A 4-week assay for screening tumor promoters of bladder cancer has been developed in which increased agglutinability of isolated rat bladder cells with concanavalin A is used as an indicator. On the basis of this assay system, L-isoleucine and L-leucine were suspected of being possible tumor promoters. Results of 40- to 60-week carcinogenesis experiments in which N-butyl-N-(4-hydroxybutyl)nitrosamine was used as an initiator demonstrate that L-isoleucine and L-leucine promote bladder cancer in rats. This finding may be relevant to the high incidence of human bladder cancer in Western countries, where the diet is rich in protein.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Effects of Branched-Chain Amino Acids on Canine Neoplastic Cell Proliferation and Death.
J. J. Wakshlag, F. A. Kallfelz, R. R. Wakshlag, and G. M. Davenport (2006)
J. Nutr. 136, 2007S-2010S
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Microbial Amino Acid Metabolites and Bladder Cancer: No Evidence of Promoting Activity in Man.
A.G. Renwick, A. Thakrar, C.A. Lawrie, and C.F. George (1988)
Human and Experimental Toxicology 7, 267-272
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Dietary and Metabolic Manipulations of the Carcinogenic Process: Role of Nucleotide Pool Imbalances in Carcinogenesis.
P. M. Rao, E. Laconi, S. Vasudevan, A. Denda, S. Rajagopal, S. Rajalakshmi, and D. S. R. Sarma (1987)
Toxicol Pathol 15, 190-193
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Studies on environmental chemical carcinogenesis in Japan.
T Sugimura (1986)
Science 233, 312-318
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