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Science 21 February 1986:
Vol. 231. no. 4740, pp. 840 - 843
DOI: 10.1126/science.3945811
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Articles

Science, Vol 231, Issue 4740, 840-843
Copyright © 1986 by American Association for the Advancement of Science

articles

Maturational changes in cerebral function in infants determined by 18FDG positron emission tomography

HT Chugani and ME Phelps

2-Deoxy-2[18F]fluoro-D-glucose positron emission tomography performed in human infants during development revealed progressive changes in local cerebral glucose utilization. In infants 5 weeks of age and younger, glucose utilization was highest in the sensorimotor cortex, thalamus, midbrain-brainstem, and cerebellar vermis. By 3 months, glucose metabolic activity had increased in the parietal, temporal, and occipital cortices and the basal ganglia, with subsequent increases in frontal and various association regions occurring by 8 months. These functional changes measured with positron emission tomography are in agreement with behavioral, neurophysiological, and anatomical alterations known to occur during infant development.


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