Science 14 February 1986: Vol. 231. no. 4739, pp. 733 - 735 DOI: 10.1126/science.3003909

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Sphingosine-1-phosphate inhibits high glucose-mediated ERK1/2 action in endothelium through induction of MAP kinase phosphatase-3.

A. M. Whetzel, D. T. Bolick, and C. C. Hedrick (2009)
Am J Physiol Cell Physiol 296, C339-C345
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Protection of IFN-{gamma} signaling-deficient NOD mice from diabetes by cyclophosphamide.

Y. Mori, T. Kato, T. Kodaka, E. M. Kanagawa, S. Hori, and O. Kanagawa (2008)
Int. Immunol. 20, 1231-1237
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Induction of Robust Diabetes Resistance and Prevention of Recurrent Type 1 Diabetes Following Islet Transplantation by Gene Therapy.

C. Tian, M. J. I. Ansari, J. Paez-Cortez, J. Bagley, J. Godwin, M. Donnarumma, M. H. Sayegh, and J. Iacomini (2007)
J. Immunol. 179, 6762-6769
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In Vivo Cytotoxicity of Insulin-Specific CD8+ T-Cells in HLA-A*0201 Transgenic NOD Mice.

I. Jarchum, J. C. Baker, T. Yamada, T. Takaki, M. P. Marron, D. V. Serreze, and T. P. DiLorenzo (2007)
Diabetes 56, 2551-2560
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The Type 1 Diabetes Locus Idd6 Controls TLR1 Expression.

D. Vallois, C. H. Grimm, P. Avner, C. Boitard, and U. C. Rogner (2007)
J. Immunol. 179, 3896-3903
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Conformation of MHC class II I-Ag7 is sensitive to the P9 anchor amino acid in bound peptide.

A. Gardiner, K. A. Richards, A. J. Sant, and L. S. Arneson (2007)
Int. Immunol. 19, 1103-1113
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Two genetic loci independently confer susceptibility to autoimmune gastritis.

D. K. Y. Ang, T. C. Brodnicki, M. A. Jordan, W. E. Wilson, P. Silveira, B. L. Gliddon, A. G. Baxter, and I. R. van Driel (2007)
Int. Immunol. 19, 1135-1144
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Modulatory Role of DR4- to DQ8-restricted CD4 T-Cell Responses and Type 1 Diabetes Susceptibility.

X. Ge, J. D. Piganelli, H. M. Tse, S. Bertera, C. E. Mathews, M. Trucco, L. Wen, and W. A. Rudert (2006)
Diabetes 55, 3455-3462
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Partial versus Full Allogeneic Hemopoietic Chimerization Is a Preferential Means to Inhibit Type 1 Diabetes as the Latter Induces Generalized Immunosuppression.

D. V. Serreze, M. A. Osborne, Y.-G. Chen, H. D. Chapman, T. Pearson, M. A. Brehm, and D. L. Greiner (2006)
J. Immunol. 177, 6675-6684
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Identification of the transcription factor ARNTL2 as a candidate gene for the type 1 diabetes locus Idd6.

M.-S. Hung, P. Avner, and U. C. Rogner (2006)
Hum. Mol. Genet. 15, 2732-2742
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Prevention of Type 1 Diabetes with Major Histocompatibility Complex-Compatible and Nonmarrow Ablative Hematopoietic Stem Cell Transplants.

G. F. Beilhack, R. R. Landa, M. A. Masek, and J. A. Shizuru (2005)
Diabetes 54, 1770-1779
 |  Abstract »  |  Full Text »  |  PDF »

Dissection of the role of MHC class II A and E genes in autoimmune susceptibility in murine lupus models with intragenic recombination.

D. Zhang, K. Fujio, Y. Jiang, J. Zhao, N. Tada, K. Sudo, H. Tsurui, K. Nakamura, K. Yamamoto, H. Nishimura, et al. (2004)
PNAS 101, 13838-13843
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Establishment of an Animal Model Using Recombinant NOD.B10.D2 Mice To Study Initial Adhesion of Oral Streptococci.

M. A. Salam, N. Matsumoto, K. Matin, Y. Tsuha, R. Nakao, N. Hanada, and H. Senpuku (2004)
Clin. Vaccine Immunol. 11, 379-386
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Autoantibodies and CD4 T cells target a {beta} cell retroviral envelope protein in non-obese diabetic mice.

M. G. Levisetti, A. Suri, I. Vidavsky, M. L. Gross, O. Kanagawa, and E. R. Unanue (2003)
Int. Immunol. 15, 1473-1483
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Evidence for a primary islet autoantigen (preproinsulin 1) for insulitis and diabetes in the nonobese diabetic mouse.

H. Moriyama, N. Abiru, J. Paronen, K. Sikora, E. Liu, D. Miao, D. Devendra, J. Beilke, R. Gianani, R. G. Gill, et al. (2003)
PNAS 100, 10376-10381
 |  Abstract »  |  Full Text »  |  PDF »

Diabetes Protection and Restoration of Thymocyte Apoptosis in NOD Idd6 Congenic Strains.

M.-L. Bergman, N. Duarte, S. Campino, M. Lundholm, V. Motta, K. Lejon, C. Penha-Goncalves, and D. Holmberg (2003)
Diabetes 52, 1677-1682
 |  Abstract »  |  Full Text »  |  PDF »

Fetal or Neonatal Low-Glycotoxin Environment Prevents Autoimmune Diabetes in NOD Mice.

M. Peppa, C. He, M. Hattori, R. McEvoy, F. Zheng, and H. Vlassara (2003)
Diabetes 52, 1441-1448
 |  Abstract »  |  Full Text »  |  PDF »

Genetic Dissection of V{alpha}14J{alpha}18 Natural T Cell Number and Function in Autoimmune-Prone Mice.

N. Matsuki, A. K. Stanic, M. E. Embers, L. Van Kaer, L. Morel, and S. Joyce (2003)
J. Immunol. 170, 5429-5437
 |  Abstract »  |  Full Text »  |  PDF »

Beta cell MHC class I is a late requirement for diabetes.

E. E. Hamilton-Williams, S. E. Palmer, B. Charlton, and R. M. Slattery (2003)
PNAS 100, 6688-6693
 |  Abstract »  |  Full Text »  |  PDF »

Renal Lesions in Spontaneous Insulin-dependent Diabetes Mellitus in the Nonobese Diabetic Mouse: Acute Phase of Diabetes.

M. Maeda, A. Yabuki, S. Suzuki, M. Matsumoto, K. Taniguchi, and H. Nishinakagawa (2003)
Vet. Pathol. 40, 187-195
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Evidence for shared recognition of a peptide ligand by a diverse panel of non-obese diabetic mice-derived, islet-specific, diabetogenic T cell clones.

K. Yoshida, T. Martin, K. Yamamoto, C. Dobbs, C. Munz, N. Kamikawaji, N. Nakano, H.-G. Rammensee, T. Sasazuki, K. Haskins, et al. (2002)
Int. Immunol. 14, 1439-1447
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Failure to Censor Forbidden Clones of CD4 T Cells in Autoimmune Diabetes.

S. Lesage, S. B. Hartley, S. Akkaraju, J. Wilson, M. Townsend, and C. C. Goodnow (2002)
J. Exp. Med. 196, 1175-1188
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Genetic Analysis of Autoimmune Sialadenitis in Nonobese Diabetic Mice: A Major Susceptibility Region on Chromosome 1.

O. Boulard, G. Fluteau, L. Eloy, D. Damotte, P. Bedossa, and H.-J. Garchon (2002)
J. Immunol. 168, 4192-4201
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Human DQ8 Can Substitute for Murine I-Ag7 in the Selection of Diabetogenic T Cells Restricted to I-Ag71.

L. Wen, F. S. Wong, R. Sherwin, and C. Mora (2002)
J. Immunol. 168, 3635-3640
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T-Cell Tolerance by Dendritic Cells and Macrophages as a Mechanism for the Major Histocompatibility Complex-Linked Resistance to Autoimmune Diabetes.

S. Thiessen, P. Serra, A. Amrani, J. Verdaguer, and P. Santamaria (2002)
Diabetes 51, 325-338
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In APCs, the Autologous Peptides Selected by the Diabetogenic I-Ag7 Molecule Are Unique and Determined by the Amino Acid Changes in the P9 Pocket.

A. Suri, I. Vidavsky, K. van der Drift, O. Kanagawa, M. L. Gross, and E. R. Unanue (2002)
J. Immunol. 168, 1235-1243
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Congenic Mapping of the Diabetogenic Locus Idd4 to a 5.2-cM Region of Chromosome 11 in NOD Mice: Identification of Two Potential Candidate Subloci.

M. Grattan, Q.-S. Mi, C. Meagher, and T. L. Delovitch (2002)
Diabetes 51, 215-223
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Relative resistance to nasally induced tolerance in non-obese diabetic mice but not other I-Ag7-expressing mouse strains.

A. Quinn, M. Melo, D. Ethell, and Eli. E. Sercarz (2001)
Int. Immunol. 13, 1321-1333
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IL-12 Administration Reveals Diabetogenic T Cells in Genetically Resistant I-E{alpha}-Transgenic Nonobese Diabetic Mice: Resistance to Autoimmune Diabetes Is Associated with Binding of E{alpha}-Derived Peptides to the I-Ag7 Molecule.

S. Trembleau, S. Gregori, G. Penna, I. Gorny, and L. Adorini (2001)
J. Immunol. 167, 4104-4114
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A correlation between the relative predisposition of MHC class II alleles to type 1 diabetes and the structure of their proteins.

F. Cucca, R. Lampis, M. Congia, E. Angius, S. Nutland, S. C. Bain, A. H. Barnett, and J. A. Todd (2001)
Hum. Mol. Genet. 10, 2025-2037
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Inhibition of Autoimmune Diabetes in Nonobese Diabetic Mice by Transgenic Restoration of H2-E MHC Class II Expression: Additive, But Unequal, Involvement of Multiple APC Subtypes.

E. A. Johnson, P. Silveira, H. D. Chapman, E. H. Leiter, and D. V. Serreze (2001)
J. Immunol. 167, 2404-2410
 |  Abstract »  |  Full Text »  |  PDF »

Peptide and Major Histocompatibility Complex-Specific Breaking of Humoral Tolerance to Native Insulin With the B9-23 Peptide in Diabetes-Prone and Normal Mice.

N. Abiru, A. K. Maniatis, L. Yu, D. Miao, H. Moriyama, D. Wegmann, and G. S. Eisenbarth (2001)
Diabetes 50, 1274-1281
 |  Abstract »  |  Full Text »

Nonobese Diabetic Mice Display Elevated Levels of Class II-Associated Invariant Chain Peptide Associated with I-Ag7 on the Cell Surface.

A. Bhatnagar, P. J. Milburn, M. Lobigs, R. V. Blanden, and A. M. Gautam (2001)
J. Immunol. 166, 4490-4497
 |  Abstract »  |  Full Text »  |  PDF »

The MHC Class II Molecule I-Ag7 Exists in Alternate Conformations That Are Peptide Dependent.

L. S. Arneson, M. Peterson, and A. J. Sant (2000)
J. Immunol. 165, 2059-2067
 |  Abstract »  |  Full Text »  |  PDF »

Linkage Analysis of Systemic Lupus Erythematosus Induced in Diabetes-Prone Nonobese Diabetic Mice by Mycobacterium bovis.

M. A. Jordan, P. A. Silveira, D. P. Shepherd, C. Chu, S. J. Kinder, J. Chen, L. J. Palmisano, L. D. Poulton, and A. G. Baxter (2000)
J. Immunol. 165, 1673-1684
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The motif for peptide binding to the insulin-dependent diabetes mellitus-associated class II MHC molecule I-Ag7 validated by phage display library.

S. Gregori, E. Bono, F. Gallazzi, J. Hammer, L. C. Harrison, and L. Adorini (2000)
Int. Immunol. 12, 493-503
 |  Abstract »  |  Full Text »  |  PDF »

Protection of Nonobese Diabetic Mice from Diabetes by Gene(s) Closely Linked to IFN-{gamma} Receptor Loci.

O. Kanagawa, G. Xu, A. Tevaarwerk, and B. A. Vaupel (2000)
J. Immunol. 164, 3919-3923
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Cutting Edge: Homologous Recombination of the MHC Class I K Region Defines New MHC-Linked Diabetogenic Susceptibility Gene(s) in Nonobese Diabetic Mice.

M. Hattori, E. Yamato, N. Itoh, H. Senpuku, T. Fujisawa, M. Yoshino, M. Fukuda, E. Matsumoto, T. Toyonaga, I. Nakagawa, et al. (1999)
J. Immunol. 163, 1721-1724
 |  Abstract »  |  Full Text »  |  PDF »

The role of MHC class II molecules in susceptibility to type I diabetes: Identification of peptide epitopes and characterization of the T cell repertoire.

C.-C. Chao, H.-K. Sytwu, E. L. Chen, J. Toma, and H. O. McDevitt (1999)
PNAS 96, 9299-9304
 |  Abstract »  |  Full Text »  |  PDF »

I-Ag7-Mediated Antigen Presentation by B Lymphocytes Is Critical in Overcoming a Checkpoint in T Cell Tolerance to Islet {beta} Cells of Nonobese Diabetic Mice.

H. Noorchashm, Y. K. Lieu, N. Noorchashm, S. Y. Rostami, S. A. S. Greeley, A. Schlachterman, H. K. Song, L. E. Noto, A. M. Jevnikar, C. F. Barker, et al. (1999)
J. Immunol. 163, 743-750
 |  Abstract »  |  Full Text »  |  PDF »

A Peptide Binding Motif for I-Eg7, the MHC Class II Molecule That Protects E{alpha}-Transgenic Nonobese Diabetic Mice from Autoimmune Diabetes.

S. Gregori, S. Trembleau, G. Penna, F. Gallazzi, J. Hammer, G. K. Papadopoulos, and L. Adorini (1999)
J. Immunol. 162, 6630-6640
 |  Abstract »  |  Full Text »  |  PDF »

Cutting Edge: Thymic Positive Selection and Peripheral Activation of Islet Antigen-Specific T Cells: Separation of Two Diabetogenic Steps by an I-Ag7 Class II MHC {beta}-Chain Mutant.

O. Kanagawa, B. A. Vaupel, G. Xu, E. R. Unanue, and J. D. Katz (1998)
J. Immunol. 161, 4489-4492
 |  Abstract »  |  Full Text »  |  PDF »

Evidence for the Presence of Insulin-Dependent Diabetes-Associated Alleles on the Distal Part of Mouse Chromosome 6.

E. Melanitou, F. Joly, M. Lathrop, C. Boitard, and P. Avner (1998)
Genome Res. 8, 608-620
 |  Abstract »  |  Full Text »

Autoreactivity of T cells from nonobese diabetic mice: An I-Ag7-dependent reaction.

O. Kanagawa, S. M. Martin, B. A. Vaupel, E. Carrasco-Marin, and E. R. Unanue (1998)
PNAS 95, 1721-1724
 |  Abstract »  |  Full Text »  |  PDF »

Major Histocompatibility Complex Class II Molecules Can Protect from Diabetes by Positively Selecting T Cells with Additional Specificities.

F. Luhder, J. Katz, C. Benoist, and D. Mathis (1998)
J. Exp. Med. 187, 379-387
 |  Abstract »  |  Full Text »  |  PDF »

A Mechanism for the Major Histocompatibility Complex-linked Resistance to Autoimmunity.

D. Schmidt, J. Verdaguer, N. Averill, and P. Santamaria (1997)
J. Exp. Med. 186, 1059-1075
 |  Abstract »  |  Full Text »  |  PDF »

Requirement of Fas for the Development of Autoimmune Diabetes in Nonobese Diabetic Mice.

N. Itoh, A. Imagawa, T. Hanafusa, M. Waguri, K. Yamamoto, H. Iwahashi, M. Moriwaki, H. Nakajima, J. Miyagawa, M. Namba, et al. (1997)
J. Exp. Med. 186, 613-618
 |  Abstract »  |  Full Text »  |  PDF »

Abnormal T cell selection on nod thymic epithelium is sufficient to induce autoimmune manifestations in C57BL/6 athymic nude mice.

V. Thomas-Vaslin, D. Damotte, M. Coltey, N. M. Le Douarin, A. Coutinho, and J. Salaun (1997)
PNAS 94, 4598-4603
 |  Abstract »  |  Full Text »  |  PDF »

Prevention of Type I Diabetes and Recurrent {beta}-Cell Destruction of Transplanted Islets.

R. H. Slover and G. S. Eisenbarth (1997)
Endocr. Rev. 18, 241-258
 |  Abstract »  |  Full Text »

T cell receptor restriction of diabetogenic autoimmune NOD T cells.

E. Simone, D. Daniel, N. Schloot, P. Gottlieb, S. Babu, E. Kawasaki, D. Wegmann, and G. S. Eisenbarth (1997)
PNAS 94, 2518-2521
 |  Abstract »  |  Full Text »  |  PDF »

T helper cell subsets in insulin-dependent diabetes.

J. Katz, C Benoist, and D Mathis (1995)
Science 268, 1185-1188
 |  Abstract »  |  PDF »

Linkage on chromosome 3 of autoimmune diabetes and defective Fc receptor for IgG in NOD mice.

J. Prins, J. Todd, N. Rodrigues, S Ghosh, P. Hogarth, L. Wicker, E Gaffney, P. Podolin, P. Fischer, A Sirotina, et al. (1993)
Science 260, 695-698
 |  Abstract »  |  PDF »

Linkage of faulty major histocompatibility complex class I to autoimmune diabetes.

D Faustman, X. Li, H. Lin, Y. Fu, G Eisenbarth, J Avruch, and J Guo (1991)
Science 254, 1756-1761
 |  Abstract »  |  PDF »

MHC-linked protection from diabetes dissociated from clonal deletion of T cells.

J Bohme, B Schuhbaur, O Kanagawa, C Benoist, and D Mathis (1990)
Science 249, 293-295
 |  Abstract »  |  PDF »

A molecular basis for MHC class II--associated autoimmunity.

J. Todd, H Acha-Orbea, J. Bell, N Chao, Z Fronek, C. Jacob, M McDermott, A. Sinha, L Timmerman, L Steinman, et al. (1988)
Science 240, 1003-1009
 |  Abstract »  |  PDF »

Immunotherapy of the nonobese diabetic mouse: treatment with an antibody to T-helper lymphocytes.

J. Shizuru, C Taylor-Edwards, B. Banks, A. Gregory, and C. Fathman (1988)
Science 240, 659-662
 |  Abstract »  |  PDF »

Three recessive loci required for insulin-dependent diabetes in nonobese diabetic mice.

M Prochazka, E. Leiter, D. Serreze, and D. Coleman (1987)
Science 237, 286-289
 |  Abstract »  |  PDF »

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