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Science 14 February 1986:
Vol. 231. no. 4739, pp. 722 - 725
DOI: 10.1126/science.3945805
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Articles

Science, Vol 231, Issue 4739, 722-725
Copyright © 1986 by American Association for the Advancement of Science

articles

Adrenal-mediated endogenous metabolites inhibit puberty in female mice

M Novotny, B Jemiolo, S Harvey, D Wiesler, and A Marchlewska-Koj

While assessing a potential role of adrenal glands in the production of the hitherto unidentified puberty-delaying pheromone of female mice, the urinary volatile profiles of normal and adrenalectomized animals were quantitatively compared. Six components, whose concentrations were depressed after adrenalectomy, were identified: 2-heptanone, trans-5-hepten-2-one, trans-4-hepten-2-one, n-pentyl acetate, cis-2-penten-1-yl acetate, and 2,5-dimethylpyrazine. When these laboratory-synthesized chemicals were added (in their natural concentrations) to either previously inactive urine from adrenalectomized females or plain water, the biological activity was fully restored.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A Recombinant Courtship Pheromone Affects Sexual Receptivity in a Plethodontid Salamander.
L. D. Houck, R. A. Watts, S. J. Arnold, K. E. Bowen, K. M. Kiemnec, H. A. Godwin, P. W. Feldhoff, and R. C. Feldhoff (2008)
Chem Senses 33, 623-631
   Abstract »    Full Text »    PDF »
Sulfated Steroids as Natural Ligands of Mouse Pheromone-Sensing Neurons.
F. Nodari, F.-F. Hsu, X. Fu, T. F. Holekamp, L.-F. Kao, J. Turk, and T. E. Holy (2008)
J. Neurosci. 28, 6407-6418
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Putative Chemical Signals about Sex, Individuality, and Genetic Background in the Preputial Gland and Urine of the House Mouse (Mus musculus).
J.-X. Zhang, X.-P. Rao, L. Sun, C.-H. Zhao, and X.-W. Qin (2007)
Chem Senses 32, 293-303
   Abstract »    Full Text »    PDF »
Removal of the Vomeronasal Organ Blocks the Stress-Induced Hyperthermia Response to Alarm Pheromone in Male Rats.
Y. Kiyokawa, T. Kikusui, Y. Takeuchi, and Y. Mori (2007)
Chem Senses 32, 57-64
   Abstract »    Full Text »    PDF »
Pheromone detection in male mice depends on signaling through the type 3 adenylyl cyclase in the main olfactory epithelium..
Z. Wang, C. Balet Sindreu, V. Li, A. Nudelman, G. C.-K. Chan, and D. R. Storm (2006)
J. Neurosci. 26, 7375-7379
   Abstract »    Full Text »    PDF »
Growth and Angiogenesis Are Inhibited in Vivo in Developing Tissues by Pyrazine and Its Derivatives.
G. Melkonian, H. Eckelhoefer, M. Wu, Y. Wang, C. Tong, K. Riveles, and P. Talbot (2003)
Toxicol. Sci. 75, 393-401
   Abstract »    Full Text »    PDF »
Bile Acid Secreted by Male Sea Lamprey That Acts as a Sex Pheromone.
W. Li, A. P. Scott, M. J. Siefkes, H. Yan, Q. Liu, S.-S. Yun, and D. A. Gage (2002)
Science 296, 138-141
   Abstract »    Full Text »    PDF »
Co-Expression of Putative Pheromone Receptors in the Sensory Neurons of the Vomeronasal Organ.
S. Martini, L. Silvotti, A. Shirazi, N. J. P. Ryba, and R. Tirindelli (2001)
J. Neurosci. 21, 843-848
   Abstract »    Full Text »    PDF »
Role of the Adrenal Gland and Adrenal-Mediated Chemosignals in Suppression of Estrus in the House Mouse: The Lee-Boot Effect Revisited.
W. Ma, Z. Miao, and M. V. Novotny (1998)
Biol Reprod 59, 1317-1320
   Abstract »    Full Text »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)