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Science 7 February 1986:
Vol. 231. no. 4738, pp. 607 - 609
DOI: 10.1126/science.3003907
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Articles

Science, Vol 231, Issue 4738, 607-609
Copyright © 1986 by American Association for the Advancement of Science

articles

Stress-induced inhibition of reproductive functions: role of endogenous corticotropin-releasing factor

C Rivier, J Rivier, and W Vale

In the adult castrated male rat, exposure to inescapable, intermittent electroshocks inhibited the pulsatile pattern of luteinizing hormone release and markedly lowered its plasma concentrations. The central administration of the corticotropin-releasing factor (CRF) antagonist alpha-helical ovine CRF residues 9 to 41 reversed the inhibitory action of stress. Neither its peripheral injection, nor the intraventricular injection of the inactive CRF analog des-Glu to Arg ovine CRF was effective. These results suggest that endogenous CRF may mediate some deleterious effects of noxious stimuli on reproduction.


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