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Science 7 February 1986:
Vol. 231. no. 4738, pp. 594 - 596
DOI: 10.1126/science.2418501
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Articles

Science, Vol 231, Issue 4738, 594-596
Copyright © 1986 by American Association for the Advancement of Science

articles

Putative reverse transcriptase intermediates of human hepatitis B virus in primary liver carcinomas

H Will, J Salfeld, E Pfaff, C Manso, L Theilmann, and H Schaler

Nucleocapsid-pol fusion proteins have been detected by serological screening hepatocellular carcinoma tissues that contain hepatitis B virus (HBV) DNA. The existence of these fusion proteins suggests that HBV may synthesize its reverse transcriptase in a fashion analogous to the way that retroviruses synthesize and process a precursor. The accumulation of HBV reverse transcriptase intermediates in tumorous tissues and not in other tissues may be related to the absence of viral core particles and possibly contributes to tumor development.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Hepatocellular Carcinoma and Hepatitis Virus.
R. B. Birrer, D. Birrer, and J. V. Klavins (2003)
Ann. Clin. Lab. Sci. 33, 39-54
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Hepatocellular Carcinoma.
A. M. DI BISCEGLIE, V. K. RUSTGI, J. H. HOOFNAGLE, G. M. DUSHEIKO, and M. T. LOTZE (1988)
Ann Intern Med 108, 390-401
   Abstract »    PDF »
Proteolytic self-cleavage of hepatitis B virus core protein may generate serum e antigen.
R. Miller (1987)
Science 236, 722-725
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