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Science 7 February 1986:
Vol. 231. no. 4738, pp. 589 - 594
DOI: 10.1126/science.3003905
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Articles

Science, Vol 231, Issue 4738, 589-594
Copyright © 1986 by American Association for the Advancement of Science

articles

Equine infectious anemia virus gag and pol genes: relatedness to visna and AIDS virus

RM Stephens, JW Casey, and NR Rice

Comparison of HTLV-III, the putative AIDS virus, with other related viruses, may help to reveal more about the origin of AIDS in humans. In this study, the nucleotide sequence of the gag and pol genes of an equine infectious anemia virus (EIAV) proviral DNA clone was determined. The sequence was compared with that of HTLV-III and of visna, a pathogenic lentivirus of sheep. The results show that these viruses constitute a family clearly distinct from that of the type C viruses or the BLV-HTLV-I and -II group. Within the family, EIAV, HTLV-III, and visna appear to be equally divergent from a common evolutionary ancestor.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Characterization of RNA Elements That Regulate Gag-Pol Ribosomal Frameshifting in Equine Infectious Anemia Virus.
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J. Virol. 77, 10280-10287
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Role of the Reverse Transcriptase, Nucleocapsid Protein, and Template Structure in the Two-step Transfer Mechanism in Retroviral Recombination.
R. H. Roda, M. Balakrishnan, M. N. Hanson, B. M. Wohrl, S. F. J. Le Grice, B. P. Roques, R. J. Gorelick, and R. A. Bambara (2003)
J. Biol. Chem. 278, 31536-31546
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Structure of Equine Infectious Anemia Virus Matrix Protein.
H. Hatanaka, O. Iourin, Z. Rao, E. Fry, A. Kingsman, and D. I. Stuart (2002)
J. Virol. 76, 1876-1883
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Gag Protein Epitopes Recognized by CD4+ T-Helper Lymphocytes from Equine Infectious Anemia Virus-Infected Carrier Horses.
S. M. Lonning, W. Zhang, and T. C. McGuire (1999)
J. Virol. 73, 4257-4265
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Gag Protein Epitopes Recognized by ELA-A-Restricted Cytotoxic T Lymphocytes from Horses with Long-Term Equine Infectious Anemia Virus Infection.
W. Zhang, S. M. Lonning, and T. C. McGuire (1998)
J. Virol. 72, 9612-9620
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Development and Characterization of an In Vivo Pathogenic Molecular Clone of Equine Infectious Anemia Virus.
R. F. Cook, C. Leroux, S. J. Cook, S. L. Berger, D. L. Lichtenstein, N. N. Ghabrial, R. C. Montelaro, and C. J. Issel (1998)
J. Virol. 72, 1383-1393
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Blood 90, 2357-2363
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Footprint analysis of replicating murine leukemia virus reverse transcriptase.
B. Wohrl, M. Georgiadis, A Telesnitsky, W. Hendrickson, and S. Le Grice (1995)
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The Acquired Immunodeficiency Syndrome (AIDS) Dementia Complex.
D. D. Ho, D. E. Bredesen, H. V. Vinters, and E. S. Daar (1989)
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Potential metal-binding domains in nucleic acid binding proteins.
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