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Science 7 February 1986:
Vol. 231. no. 4738, pp. 587 - 589
DOI: 10.1126/science.3003904
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Articles

Science, Vol 231, Issue 4738, 587-589
Copyright © 1986 by American Association for the Advancement of Science

articles

Translocation of protein kinase C activity may mediate hippocampal long-term potentiation

RF Akers, DM Lovinger, PA Colley, DJ Linden, and A Routtenberg

Protein kinase C activity in rat hippocampal membranes and cytosol was determined 1 minute and 1 hour after induction of the synaptic plasticity of long-term potentiation. At 1 hour after long-term potentiation, but not at 1 minute, protein kinase C activity was increased twofold in membranes and decreased proportionately in cytosol, suggesting translocation of the activity. This time-dependent redistribution of enzyme activity was directly related to the persistence of synaptic plasticity, suggesting a novel mechanism regulating the strength of synaptic transmission.


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Stimulation of protein tyrosine phosphorylation by NMDA receptor activation.
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Long-term synaptic potentiation.
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A spatial-temporal model of cell activation.
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Long-term potentiation in dentate gyrus: induction by asynchronous volleys in separate afferents.
J Winson and D Dahl (1986)
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Studies and perspectives of protein kinase C.
Y Nishizuka (1986)
Science 233, 305-312
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