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Science 7 February 1986:
Vol. 231. no. 4738, pp. 574 - 579
DOI: 10.1126/science.2868525
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Articles

Science, Vol 231, Issue 4738, 574-579
Copyright © 1986 by American Association for the Advancement of Science

articles

Mechanism of transmitter release: voltage hypothesis and calcium hypothesis

RS Zucker and L Lando

The calcium hypothesis of synaptic transmission has been challenged by experimental results using the crayfish neuromuscular junction that suggest that presynaptic depolarization can trigger transmitter release directly without calcium influx. Results from electrophysiological experiments using the same preparation do not support this voltage hypothesis, but are consistent with the calcium hypothesis. Voltage may modulate, but not elicit, transmitter release.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Different VAMP/Synaptobrevin Complexes for Spontaneous and Evoked Transmitter Release at the Crayfish Neuromuscular Junction.
S.-Y. Hua, D. A. Raciborska, W. S. Trimble, and M. P. Charlton (1998)
J Neurophysiol 80, 3233-3246
   Abstract »    Full Text »    PDF »
Spontaneous acetylcholine release in mammalian neuromuscular junctions.
A. Losavio and S. Muchnik (1997)
Am J Physiol Cell Physiol 273, C1835-C1841
   Abstract »    Full Text »    PDF »


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