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Science 31 January 1986:
Vol. 231. no. 4737, pp. 476 - 479
DOI: 10.1126/science.3001938
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Articles
Science, Vol 231, Issue 4737, 476-479
Copyright © 1986 by American Association for the Advancement of Science
Irreversible block of the mycelial-to-yeast phase transition of Histoplasma capsulatum
G Medoff,
M Sacco,
B Maresca,
D Schlessinger,
A Painter,
GS Kobayashi,
and
L Carratu
p-Chloromercuriphenylsulfonic acid (PCMS), a sulfhydryl inhibitor, prevented the mycelial-to-yeast transition of the dimorphic fungal pathogen, Histoplasma capsulatum. The effect of PCMS was specific for the mycelial-to-yeast transformation; it had no effect on growth of either the yeast or mycelial forms or on the yeast-to-mycelial transition. The failure of PCMS-treated mycelia to transform to yeast was permanent and irreversible. PCMS-treated mycelia could not infect mice but could stimulate resistance to infection by a pathogenic strain of Histoplasma capsulatum. These results suggest a new general strategy for vaccine development in diseases caused by dimorphic pathogens.
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