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Science 24 January 1986:
Vol. 231. no. 4736, pp. 405 - 407
DOI: 10.1126/science.3941904
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Articles

Science, Vol 231, Issue 4736, 405-407
Copyright © 1986 by American Association for the Advancement of Science

articles

Reductions in arterial diameter produced by chronic decreases in blood flow are endothelium-dependent

BL Langille and F O'Donnell

A 70 percent reduction in the rate of blood flow through the common carotid artery in rabbits caused a 21 percent decrease in the diameter of this artery within 2 weeks. The smooth muscle relaxant papaverine did not attenuate the response; therefore, such reductions in diameter probably reflect a structural modification of the arterial wall rather than sustained contraction of smooth muscle. This arterial response to reduced blood flow was abolished when the endothelium was removed from the vessels. It appears that the endothelium is essential for the compensatory arterial response to long-term changes in luminal blood flow rates.


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J. L. Tuttle, R. D. Nachreiner, A. S. Bhuller, K. W. Condict, B. A. Connors, B. P. Herring, M. C. Dalsing, and J. L. Unthank (2001)
Am J Physiol Heart Circ Physiol 281, H1380-H1389
   Abstract »    Full Text »    PDF »
Impaired Function of Endothelial Pressure-Activated Cation Channel in Salt-Sensitive Genetic Hypertension.
R. KOHLER, R. KREUTZ, A. GRUNDIG, L. ROTHERMUND, C. YAGIL, Y. YAGIL, A. R. PRIES, and J. HOYER (2001)
J. Am. Soc. Nephrol. 12, 1624-1629
   Abstract »    Full Text »    PDF »
Vascular Smooth Muscle Growth: Autocrine Growth Mechanisms.
B. C. Berk (2001)
Physiol Rev 81, 999-1030
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Blood Flow Decrease Induces Apoptosis of Endothelial Cells in Previously Dilated Arteries Resulting From Chronic High Blood Flow.
E. Sho, M. Sho, T. M. Singh, C. Xu, C. K. Zarins, and H. Masuda (2001)
Arterioscler Thromb Vasc Biol 21, 1139-1145
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Regular endurance exercise induces expansive arterial remodelling in the trained limbs of healthy men.
F. A Dinenno, H. Tanaka, K. D Monahan, C. M Clevenger, I. Eskurza, C. A DeSouza, and D. R Seals (2001)
J. Physiol. 534, 287-295
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Go With the Flow.
J. P. Cooke and P. S. Tsao (2001)
Circulation 103, 2773-2775
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Effects of one-legged endurance training on femoral arterial and venous size in healthy humans.
M. Miyachi, H. Tanaka, K. Yamamoto, A. Yoshioka, K. Takahashi, and S. Onodera (2001)
J Appl Physiol 90, 2439-2444
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Adaptive common carotid arteries remodeling after unilateral internal carotid artery occlusion in adult patients.
N. Kubis, A. Checoury, A. Tedgui, and B. I. Levy (2001)
Cardiovasc Res 50, 597-602
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Inaugural Article: Biomechanical activation of vascular endothelium as a determinant of its functional phenotype.
G. Garcia-Cardena, J. Comander, K. R. Anderson, B. R. Blackman, and M. A. Gimbrone Jr. (2001)
PNAS 98, 4478-4485
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Endothelial dysfunction in patients with sickle cell disease is related to selective impairment of shear stress-mediated vasodilation.
L. Belhassen, G. Pelle, S. Sediame, D. Bachir, C. Carville, C. Bucherer, C. Lacombe, F. Galacteros, and S. Adnot (2001)
Blood 97, 1584-1589
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