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Science 24 January 1986:
Vol. 231. no. 4736, pp. 397 - 400
DOI: 10.1126/science.2934816
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Articles

Science, Vol 231, Issue 4736, 397-400
Copyright © 1986 by American Association for the Advancement of Science

articles

A blood vessel model constructed from collagen and cultured vascular cells

CB Weinberg and E Bell

A model of a blood vessel was constructed in vitro. Its multilayered structure resembled that of an artery and it withstood physiological pressures. Electron microscopy showed that the endothelial cells lining the lumen and the smooth muscle cells in the wall were healthy and well differentiated. The lining of endothelial cells functioned physically, as a permeability barrier, and biosynthetically, producing von Willebrand's factor and prostacyclin. The strength of the model depended on its multiple layers of collagen integrated with a Dacron mesh.


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