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Science 24 January 1986:
Vol. 231. no. 4736, pp. 379 - 382
DOI: 10.1126/science.3941901
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Articles

Science, Vol 231, Issue 4736, 379-382
Copyright © 1986 by American Association for the Advancement of Science

articles

Hu-ets-1 and Hu-ets-2 genes are transposed in acute leukemias with (4;11) and (8;21) translocations

N Sacchi, DK Watson, AH Guerts van Kessel, A Hagemeijer, J Kersey, HD Drabkin, D Patterson, and TS Papas

Human probes identifying the cellular homologs of the v-ets gene, Hu-ets-1 and Hu-ets-2, and two panels of rodent-human cell hybrids were used to study specific translocations occurring in acute leukemias. The human ets-1 gene was found to translocate from chromosome 11 to 4 in the t(4;11)(q21;23), a translocation characteristic of a subtype of leukemia that represents the expansion of a myeloid/lymphoid precursor cell. Similarly, the human ets-2 gene was found to translocate from chromosome 21 to chromosome 8 in the t(8;21)(q22;q22), a nonrandom translocation commonly found in patients with acute myeloid leukemia with morphology M2 (AML-M2). Both translocations are associated with expression different from the expression in normal lymphoid cells of ets genes, raising the possibility that these genes play a role in the pathogenesis of these leukemias.


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