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Science 24 January 1986:
Vol. 231. no. 4736, pp. 365 - 368
DOI: 10.1126/science.231.4736.365
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Articles

Tissue-Specific Cell Lineages Originate in the Gastrula of the Zebrafish

CHARLES B. KIMMEL 1 and RACHEL M. WARGA 2

1 Professor in the Department of Biology and is a member of the Institute of Neuroscience University of Oregon, Eugene 97403.
2 Research assistant in the Institute of Neuroscience, University of Oregon, Eugene 97403.

In the zebrafish, cells of a clone derived from a single blastomere migrate away from one another during gastrulation. Later in development their descendants are usually found scattered within several different types of tissues of embryo. The divisions and migrations of individual cells were monitored during early development, revealing that in most cases the lineal descendants of single cells present at gastrula stage exclusively populate only single tissues, and may have stereotyped positional relationships within these tissues. Thus the gastrula stage is the first stage when heritable restrictions in cell type might arise in the zebrafish.

Submitted on April 26, 1985
Accepted on November 27, 1985


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