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Science 17 January 1986:
Vol. 231. no. 4735, pp. 261 - 265
DOI: 10.1126/science.3941898
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Articles

Science, Vol 231, Issue 4735, 261-265
Copyright © 1986 by American Association for the Advancement of Science

articles

Alterations of myc, myb, and rasHa proto-oncogenes in cancers are frequent and show clinical correlation

J Yokota, Y Tsunetsugu-Yokota, H Battifora, C Le Fevre, and MJ Cline

Alterations of c-myc, c-rasHa, or c-myb oncogenes were found in more than one-third of human solid tumors. Amplification of c-myc occurred in advanced, widespread tumors or in aggressive primary tumors. Apparent allelic deletions of c-rasHa and c-myb can be correlated with progression and metastasis of carcinomas and sarcomas.


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Mutations and Copy Number Increase of HRAS in Spitz Nevi with Distinctive Histopathological Features.
B. C. Bastian, P. E. LeBoit, and D. Pinkel (2000)
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Tumor progression and metastasis.
J. Yokota (2000)
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Distinct Cellular Factors Regulate the c-myb Promoter through Its E2F Element.
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Identification and Characterization of a Homozygous Deletion Found in Ovarian Ascites by Representational Difference Analysis.
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Myb-dependent Regulation of Thrombospondin 2 Expression. ROLE OF mRNA STABILITY.
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Expression of HGF, Its Receptor c-met, c-myc, and Albumin in Cirrhotic and Neoplastic Human Liver Tissue.
J. Y. Ljubimova, L. M. Petrovic, S. E. Wilson, S. A. Geller, and A. A. Demetriou (1997)
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MYC Amplification in Squamous Cell Carcinomas of the Head and Neck.
J. P. Rodrigo, P. S. Lazo, S. Ramos, I. Alvarez, and C. Suarez (1996)
Arch Otolaryngol Head Neck Surg 122, 504-507
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Collagen Biosynthesis in Human Oral Submucous Fibrosis Fibroblast Cultures.
M.Y.P. Kuo, H.M. Chen, L.J. Hahn, C.C. Hsieh, and C.P. Chiang (1995)
Journal of Dental Research 74, 1783-1788
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Retrieval of p53 Protein in Paraffin-Embedded Head and Neck Tumor Tissues.
Z. P. Pavelic, L. G. Portugal, M. J. Gootee, P. J. Stambrook, C. Smith, R. E. Mugge, L. Pavelic, K. Wilson, C. R. Buncher, Y.-Q. Li, et al. (1993)
Arch Otolaryngol Head Neck Surg 119, 1206-1209
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Predisposition to neoplastic transformation caused by gene replacement of H-ras1.
R. Finney and J. Bishop (1993)
Science 260, 1524-1527
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Oncogene Amplification in Squamous Cell Carcinoma of the Head and Neck.
W. D. Merritt, M. C. Weissler, B. F. Turk, and T. M. Gilmer (1990)
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Differentiation of mouse erythroleukemia cells enhanced by alternatively spliced c-myb mRNA.
B. Weber, E. Westin, and M. Clarke (1990)
Science 249, 1291-1293
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Isolation and characterization of a gene specifically expressed in different metastatic cells and whose deduced gene product has a high degree of homology to a Ca2+-binding protein family..
A Ebralidze, E Tulchinsky, M Grigorian, A Afanasyeva, V Senin, E Revazova, and E Lukanidin (1989)
Genes & Dev. 3, 1086-1093
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Reduction to homozygosity of genes on chromosome 11 in human breast neoplasia.
I. Ali, R Lidereau, C Theillet, and R Callahan (1987)
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Transformation by oncogenes encoding protein kinases induces the metastatic phenotype.
S. Egan, J. Wright, L Jarolim, K Yanagihara, R. Bassin, and A. Greenberg (1987)
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Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene.
D. Slamon, G. Clark, S. Wong, W. Levin, A Ullrich, and W. McGuire (1987)
Science 235, 177-182
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Increased Expression of the Epidermal Growth Factor Receptor on Human Colon Carcinoma Cells.
S. J. Bradley, G. Garfinkle, E. Walker, R. Salem, L. B. Chen, and G. Steele Jr (1986)
Arch Surg 121, 1242-1247
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Molecular Genetic Analysis Reveals Chromosomal Deletion, Gene Amplification, and Autocrine Growth Factor Production in the Pathogenesis of Human Lung Cancer.
J.D. Minna, J.F. Battey, B.J. Brooks, F. Cuttitta, A.F. Gazdar, B.E. Johnson, D.C. Ihde, A.-M. Lebacq-Verheyden, J. Mulshine, M.M. Nau, et al. (1986)
Cold Spring Harb Symp Quant Biol 51, 843-853
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