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Science 3 January 1986:
Vol. 231. no. 4733, pp. 57 - 59
DOI: 10.1126/science.3510452
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Articles

Science, Vol 231, Issue 4733, 57-59
Copyright © 1986 by American Association for the Advancement of Science

articles

Human monoclonal antibodies to Pf 155, a major antigen of malaria parasite Plasmodium falciparum

R Udomsangpetch, K Lundgren, K Berzins, B Wahlin, H Perlmann, M Troye-Blomberg, J Carlsson, M Wahlgren, P Perlmann, and A Bjorkman

Pf 155, a protein of the human malaria parasite Plasmodium falciparum, is strongly immunogenic in humans and is believed to be a prime candidate for the preparation of a vaccine. Human monoclonal antibodies to Pf 155 were obtained by cloning B cells that had been prepared from an immune donor and transformed with Epstein-Barr virus. When examined by indirect immunofluorescence, these antibodies stained the surface of infected erythrocytes, free merozoites, segmented schizonts, and gametocytes. They bound to a major polypeptide with a relative molecular weight of 155K and to two minor ones (135K and 120K), all having high affinity for human glycophorin. The antibodies strongly inhibited merozoite reinvasion in vitro, suggesting that they might be appropriate reagents for therapeutic administration in vivo.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Production of High-Affinity Human Monoclonal Antibody Fab Fragments to the 19-Kilodalton C-Terminal Merozoite Surface Protein 1 of Plasmodium falciparum.
X.-J. Cheng, H. Hayasaka, K. Watanabe, Y.-L. Tao, J.-Y. Liu, H. Tsukamoto, T. Horii, K. Tanabe, and H. Tachibana (2007)
Infect. Immun. 75, 3614-3620
   Abstract »    Full Text »    PDF »
OF MAURER'S CLEFTS IN PLASMODIUM FALCIPARUM-INFECTED ERYTHROCYTES.
M. HAEGGSTROM, A. VON EULER, F. KIRONDE, V. FERNANDEZ, and M. WAHLGREN (2007)
Am J Trop Med Hyg 76, 27-32
   Abstract »    Full Text »    PDF »
A comparison of the in vivo kinetics of Plasmodium falciparum ring-infected erythrocyte surface antigen-positive and -negative erythrocytes.
P. N. Newton, K. Chotivanich, W. Chierakul, R. Ruangveerayuth, P. Teerapong, K. Silamut, S. Looareesuwan, and N. J. White (2001)
Blood 98, 450-457
   Abstract »    Full Text »    PDF »


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