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Science 20 December 1985:
Vol. 230. no. 4732, pp. 1398 - 1401
DOI: 10.1126/science.3906897
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Articles

Science, Vol 230, Issue 4732, 1398-1401
Copyright © 1985 by American Association for the Advancement of Science

articles

Hematopoietic histoincompatibility reactions by NK cells in vitro: model for genetic resistance to marrow grafts

C Bordignon, JP Daley, and I Nakamura

In certain strains of mice, bone marrow grafts from parental donors fail to grow in first-generation hybrid mice. This "hybrid resistance" of nonsensitized F1 hybrid mice to the engraftment of parental hematopoietic transplants contradicts the classical laws of transplantation and is dependent on a radioresistant but immunogenetically specific effector mechanism. Studies in a new in vitro model reveal that committed hematopoietic precursors of parental origin can be inactivated by direct contact with natural killer-like splenic effectors from F1 mice. The reaction requires genetically restricted recognition, since only parental competitors syngeneic to the target bone marrow cells partially reversed this inactivation. Models of this type may be useful in studying the possible role of natural resistance in bone marrow transplantation in humans.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Altered Donor and Recipient Ly49+ NK Cell Subsets in Allogeneic H-2d -> H-2b and H-2b -> H-2d Bone Marrow Chimeras.
S. Korten, E. Wilk, J. E. Gessner, D. Meyer, and R. E. Schmidt (1999)
J. Immunol. 163, 5896-5905
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