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Science 20 December 1985:
Vol. 230. no. 4732, pp. 1391 - 1394
DOI: 10.1126/science.2999984
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Articles

Science, Vol 230, Issue 4732, 1391-1394
Copyright © 1985 by American Association for the Advancement of Science

articles

Repression of the immunoglobulin heavy chain enhancer by the adenovirus-2 E1A products

R Hen, E Borrelli, and P Chambon

The products of the adenovirus-2 (Ad2) immortalizing oncogene E1A repress the activity of the SV40, polyoma virus and E1A enhancers. Evidence is presented that Ad2 infection of MPC11 plasmocytoma cells results in an inhibition of transcription of both the gamma 2b heavy chain (IgH) and the kappa light chain immunoglobulin genes. This inhibition is caused by the Ad2 E1A products. Furthermore, the Ad2 E1A products repress transcription activated by the immunoglobulin heavy chain enhancer in chimeric recombinants, which are either stably integrated in the genome of lymphoid cells or are present as episomes. The implications of negative regulation of cellular enhancers are discussed.


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Adenovirus E1A N-Terminal Amino Acid Sequence Requirements for Repression of Transcription In Vitro and In Vivo Correlate with Those Required for E1A Interference with TBP-TATA Complex Formation.
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CREB-binding protein and p300: molecular integrators of hematopoietic transcription.
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Specificity of Cyclin E-Cdk2, TFIIB, and E1A Interactions with a Common Domain of the p300 Coactivator.
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Differential Interactions of the CREB/ATF Family of Transcription Factors with p300 and Adenovirus E1A.
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Transcriptional Repression by Human Adenovirus E1A N Terminus/Conserved Domain 1 Polypeptides in Vivo and in Vitro in the Absence of Protein Synthesis.
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Sequences Located 3` to the Breakpoint of the Hereditary Persistence of Fetal Hemoglobin-3 Deletion Exhibit Enhancer Activity and Can Modify the Developmental Expression of the Human Fetal A[IMAGE]-Globin Gene in Transgenic Mice.
N. P. Anagnou, C. Perez-Stable, R. Gelinas, F. Costantini, K. Liapaki, M. Constantopoulou, T. Kosteas, N. K. Moschonas, and , and George Stamatoyannopoulos (1995)
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Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor..
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Inhibition of muscle differentiation by the adenovirus E1a protein: repression of the transcriptional activating function of the HLH protein Myf-5..
T Braun, E Bober, and H H Arnold (1992)
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Induction of transcription factor AP-1 by adenovirus E1A protein and cAMP..
U Muller, M P Roberts, D A Engel, W Doerfler, and T Shenk (1989)
Genes & Dev. 3, 1991-2002
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Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins.
P. Mitchell and R Tjian (1989)
Science 245, 371-378
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cAMP acts in synergy with E1A protein to activate transcription of the adenovirus early genes E4 and E1A..
D A Engel, S Hardy, and T Shenk (1988)
Genes & Dev. 2, 1517-1528
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Alternative mechanisms for activation of human immunodeficiency virus enhancer in T cells.
G. Nabel, S. Rice, D. Knipe, and D Baltimore (1988)
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A quantitative bioassay for HIV-1 based on trans-activation.
B. Felber and G. Pavlakis (1988)
Science 239, 184-187
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Identification of factors that interact with the E1A-inducible adenovirus E3 promoter..
H C Hurst and N C Jones (1987)
Genes & Dev. 1, 1132-1146
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Adenovirus transforming 19-kD T antigen has an enhancer-dependent trans-activation function and relieves enhancer repression mediated by viral and cellular genes..
K Yoshida, L Venkatesh, M Kuppuswamy, and G Chinnadurai (1987)
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Activation of adenovirus promoters by the adenovirus E1A protein in cell-free extracts.
R Spangler, M Bruner, B Dalie, and M. Harter (1987)
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Regulation of inducible and tissue-specific gene expression.
T Maniatis, S Goodbourn, and J. Fischer (1987)
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Science. ISSN 0036-8075 (print), 1095-9203 (online)