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Science 20 December 1985:
Vol. 230. no. 4732, pp. 1385 - 1388
DOI: 10.1126/science.4071057
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Articles

Science, Vol 230, Issue 4732, 1385-1388
Copyright © 1985 by American Association for the Advancement of Science

articles

Brain-derived acidic fibroblast growth factor: complete amino acid sequence and homologies

G Gimenez-Gallego, J Rodkey, C Bennett, M Rios-Candelore, J DiSalvo, and K Thomas

Bovine brain-derived acidic fibroblast growth factor (aFGF) is a protein mitogen originally identified in partially purified preparations of whole brain. The protein was purified to homogeneity and shown to be a potent vascular endothelial cell mitogen in culture and angiogenic substance in vivo. The homology of aFGF to human interleukin-1 beta was inferred from partial sequence data. The complete amino acid sequence of aFGF has now been determined and observed to be similar to both basic FGF and interleukin-1's. A neuropeptide-like sequence, flanked by basic dipeptides, was observed within the aFGF sequence.


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