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Science 20 December 1985:
Vol. 230. no. 4732, pp. 1375 - 1378
DOI: 10.1126/science.2416056
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Articles

Science, Vol 230, Issue 4732, 1375-1378
Copyright © 1985 by American Association for the Advancement of Science

articles

A new class of steroids inhibits angiogenesis in the presence of heparin or a heparin fragment

R Crum, S Szabo, and J Folkman

Steroids that lack glucocorticoid or mineralocorticoid activity were found to inhibit angiogenesis in the presence of heparin or specific heparin fragments. This newly discovered steroid function appears to be governed by distinct structural configurations of the pregnane nucleus. These compounds are here named angiostatic steroids.


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