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Science 13 December 1985:
Vol. 230. no. 4731, pp. 1285 - 1287
DOI: 10.1126/science.2999979
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Articles

Science, Vol 230, Issue 4731, 1285-1287
Copyright © 1985 by American Association for the Advancement of Science

articles

Direct evidence that endogenous GM1 ganglioside can mediate thymocyte proliferation

S Spiegel, PH Fishman, and RJ Weber

The B subunit of cholera toxin, which is multivalent and binds exclusively to a specific ganglioside, GM1, was mitogenic for rat thymocytes. When exposed to the B subunit, the cells proliferated, as measured by 3H-labeled thymidine incorporation. Mitogenesis depended on the direct interaction of the B subunit with GM1 on the surface of the cells. This demonstrates that endogenous plasma membrane gangliosides can mediate proliferation in lymphocytes.


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