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Science 13 December 1985:
Vol. 230. no. 4731, pp. 1273 - 1276
DOI: 10.1126/science.2999977
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Articles
Science, Vol 230, Issue 4731, 1273-1276
Copyright © 1985 by American Association for the Advancement of Science
Alpha 2-adrenergic mechanisms in prefrontal cortex associated with cognitive decline in aged nonhuman primates
AF Arnsten
and
PS Goldman-Rakic
This study provides evidence that the alpha 2-adrenergic receptor agonist clonidine ameliorates the cognitive deficits exhibited by aged nonhuman primates through drug actions at alpha 2 receptors. Furthermore, pharmacological profiles in animals with lesions restricted to the dorsolateral prefrontal cortex indicate that this area may be the site of action for some of clonidine's beneficial effects. These results demonstrate that alpha-adrenergic systems contribute to cognitive function and suggest a new strategy for treating memory disorders in aged humans.
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