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Science 6 December 1985:
Vol. 230. no. 4730, pp. 1171 - 1173
DOI: 10.1126/science.3877981
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Articles

Science, Vol 230, Issue 4730, 1171-1173
Copyright © 1985 by American Association for the Advancement of Science

articles

Human recombinant granulocyte-macrophage colony-stimulating factor: a multilineage hematopoietin

CA Sieff, SG Emerson, RE Donahue, DG Nathan, EA Wang, GG Wong, and SC Clark

Human recombinant granulocyte-macrophage colony-stimulating factor (GM-CSF) was tested for its ability to induce colony formation in human bone marrow that had been enriched for progenitor cells. In addition to its expected granulocyte-monocyte colony-stimulating activity, the recombinant GM-CSF had burst-promoting activity for erythroid burst-forming units and also stimulated colonies derived from multipotent (mixed) progenitors. In contrast, recombinant erythroid-potentiating activity did not stimulate erythroid progenitors. The experiments prove that human GM-CSF has multilineage colony-stimulating activity.


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Tumor Cell Surface Expression of Granulocyte-Macrophage Colony-Stimulating Factor Elicits Antitumor Immunity and Protects from Tumor Challenge in the P815 Mouse Mastocytoma Tumor Model.
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The beta  Chain of the Interleukin-3 Receptor Functionally Associates With the Erythropoietin Receptor.
P. T. Jubinsky, O. I. Krijanovski, D. G. Nathan, J. Tavernier, and C. A. Sieff (1997)
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The Cytoplasmic Domain of Granulocyte-Macrophage Colony-stimulating Factor (GM-CSF) Receptor alpha  Subunit Is Essential for Both GM-CSF-mediated Growth and Differentiation.
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Ligand-independent Cell Surface Expression of the Human Soluble Granulocyte-Macrophage Colony-stimulating Factor Receptor alpha Subunit Depends on Co-expression of the Membrane-associated Receptor beta Subunit.
E. W. Murray, C. Pihl, A. Morcos, and C. B. Brown (1996)
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Recombinant Human Erythropoietin and Renal Anemia: Molecular Biology, Clinical Efficacy, and Nervous System Effects.
A. R. Nissenson, S. D. Nimer, and D. L. Wolcott (1991)
Ann Intern Med 114, 402-416
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Colony-Stimulating Factors and Host Defense.
R. H. Weisbart, J. C. Gasson, and D. W. Golde (1989)
Ann Intern Med 110, 297-303
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The human hematopoietic colony-stimulating factors.
S. Clark and R Kamen (1987)
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Retroviral transfer and expression of the interleukin-3 gene in hemopoietic cells..
P M Wong, S W Chung, and A W Nienhuis (1987)
Genes & Dev. 1, 358-365
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Recombinant human granulocyte colony-stimulating factor: effects on normal and leukemic myeloid cells.
L. Souza, T. Boone, J Gabrilove, P. Lai, K. Zsebo, D. Murdock, V. Chazin, J Bruszewski, H Lu, K. Chen, et al. (1986)
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Effects of N-linked Carbohydrate on the In Vivo Properties of Human GM-CSF.
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Assignment of the GM-CSF, CSF-1, and FMS Genes to Human Chromosome 5 Provides Evidence for Linkage of a Family of Genes Regulating Hematopoiesis and for Their Involvement in the Deletion (5q) in Myeloid Disorders.
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